Ghiringhelli P
Int J Clin Pharmacol Ther Toxicol. 1985 Jan;23(1):52-5.
We compared the results obtained in the treatment of bronchospastic conditions in two groups of 20 patients, one treated with an extempore combination of salbutamol (2 mg tablets) and oxatomide (30 mg tablets) and the other with salbutamol (2 mg tablets) alone. Positive results were obtained with the combination in 95% of cases, as against 55% in those treated with salbutamol alone. Generally speaking, treatment with the combination produced resolution of the bronchospasm, prevention of dyspnea attacks and an improvement in the respiratory status of the patients. The combination was well tolerated in all cases with no incidence of side effects, whereas in the patients on treatment with salbutamol alone, 3 cases of mild muscular tremors were observed, accompanied by tachycardia, but did not require discontinuation of the treatment.
我们比较了两组各20例支气管痉挛性疾病患者的治疗结果,一组采用沙丁胺醇(2毫克片剂)和奥沙米特(30毫克片剂)的临时组合进行治疗,另一组仅使用沙丁胺醇(2毫克片剂)进行治疗。联合用药组95%的病例取得了阳性结果,而单独使用沙丁胺醇治疗的病例这一比例为55%。一般来说,联合治疗可缓解支气管痉挛,预防呼吸困难发作,并改善患者的呼吸状况。所有病例对联合用药耐受性良好,无副作用发生,而在仅接受沙丁胺醇治疗的患者中,观察到3例轻度肌肉震颤,并伴有心动过速,但无需停药。