Lovering E G, Beaulieu N, Lawrence R C, Sears R W
J Assoc Off Anal Chem. 1985 Mar-Apr;68(2):168-71.
A liquid chromatographic (LC) procedure has been developed for the assay, content uniformity, and identification of single active ingredient solid and liquid formulations of amitriptyline, chlorpromazine, imipramine, thioridazine, and trifluoperazine. The drugs are extracted from their formulations with methanol or dilute hydrochloric acid, and identified by comparison of retention times with those of known standards; drugs are quantitated against these standards with dl-norephedrine hydrochloride as the internal standard. The precision of replicate injections is better than 2.5% for peak area and better than 1% for peak height. The precision of triplicate determinations of tablet composites is better than 2.2%.
已开发出一种液相色谱（LC）方法，用于测定阿米替林、氯丙嗪、丙咪嗪、硫利达嗪和三氟拉嗪的单一活性成分固体和液体制剂的含量、含量均匀度及鉴别。这些药物从其制剂中用甲醇或稀盐酸提取，通过将保留时间与已知标准品的保留时间进行比较来鉴别；以盐酸去甲麻黄碱作为内标物，根据这些标准品对药物进行定量。重复进样的精密度对于峰面积优于2.5%，对于峰高优于1%。片剂组合物的三次测定精密度优于2.2%。
