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婴儿期的定植和/或感染与儿童过敏性疾病的风险

colonization and/or infection during infancy and the risk of childhood allergic diseases.

作者信息

Lee Sun Hwa, Gong Yun Na, Ryoo Eell

机构信息

Department of Pediatrics, Gachon University Gil Medical Center, Gachon University, Incheon, Korea.

Graduate School of Medicine, Gachon University, Incheon, Korea.

出版信息

Korean J Pediatr. 2017 May;60(5):145-150. doi: 10.3345/kjp.2017.60.5.145. Epub 2017 May 31.

Abstract

PURPOSE

The gut microbiota can influence several diseases through immune modulation; however, the exact role of microbes such as and the relationship between microbiota colonization and allergic diseases are not well known. This study aimed to determine the relationship between colonization and/or infection (CDCI) during infancy and allergic diseases during early childhood.

METHODS

Infants 1-12 months of age presenting changes in bowel habits for more than 2 weeks were enrolled in this study. After dividing them into 2 groups according to the presence and absence of , the risk of allergic disease development during childhood was identified and compared.

RESULTS

Sixty-five patients were included in this study; 22 (33.8%) were diagnosed with CDCI. No significant differences were observed in baseline characteristics between the -positive and -negative groups except for antibiotic exposure (22.7% vs. 60.5%, =0.004). Compared to the -negative group, the risk of developing at least one allergic disease was higher in the -positive group after adjusting other variables (adjusted odds ratios, 5.61; 95% confidence interval, 1.52-20.74; =0.007). Furthermore, food allergies were more prevalent in the -positive group (=0.03).

CONCLUSION

CDCI during infancy were associated with a higher risk of developing allergic diseases during early childhood. These results suggest that CDCI during infancy might reflect the reduced diversity of the intestinal microbiota, which is associated with an increased risk of allergic sensitization. To identify the underlying mechanism, further investigation and a larger cohort study will be needed.

摘要

目的

肠道微生物群可通过免疫调节影响多种疾病;然而,诸如[具体微生物名称未给出]等微生物的确切作用以及微生物群定植与过敏性疾病之间的关系尚不清楚。本研究旨在确定婴儿期定植和/或感染(CDCI)与幼儿期过敏性疾病之间的关系。

方法

本研究纳入了1 - 12个月龄、排便习惯改变超过2周的婴儿。根据[具体因素未给出]的有无将他们分为两组,然后确定并比较儿童期发生过敏性疾病的风险。

结果

本研究共纳入65例患者;22例(33.8%)被诊断为CDCI。除抗生素暴露情况(22.7%对60.5%,P = 0.004)外,[具体因素未给出]阳性组和阴性组的基线特征未观察到显著差异。与阴性组相比,在调整其他变量后,阳性组发生至少一种过敏性疾病的风险更高(调整后的优势比为5.61;95%置信区间为1.52 - 20.74;P = 0.007)。此外,食物过敏在阳性组中更为普遍(P = 0.03)。

结论

婴儿期的CDCI与幼儿期发生过敏性疾病的较高风险相关。这些结果表明婴儿期的CDCI可能反映了肠道微生物群多样性的降低,这与过敏致敏风险增加有关。为确定潜在机制,需要进一步研究和更大规模的队列研究。

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本文引用的文献

2
Antibiotics and the Human Gut Microbiome: Dysbioses and Accumulation of Resistances.
Front Microbiol. 2016 Jan 12;6:1543. doi: 10.3389/fmicb.2015.01543. eCollection 2015.
3
Commensal bacteria protect against food allergen sensitization.
Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13145-50. doi: 10.1073/pnas.1412008111. Epub 2014 Aug 25.
4
Community-acquired Clostridium difficile infection: an increasing public health threat.
Infect Drug Resist. 2014 Mar 17;7:63-72. doi: 10.2147/IDR.S46780. eCollection 2014.
6
Maturation of Toll-like receptor 1-4 responsiveness during early life.
Early Hum Dev. 2013 Jul;89(7):473-8. doi: 10.1016/j.earlhumdev.2013.03.013. Epub 2013 Apr 13.
7
Probiotics in treatment of allergic rhinitis.
World Allergy Organ J. 2010 Sep;3(9):239-44. doi: 10.1097/WOX.0b013e3181f234d4.
8
Microbial exposure during early life has persistent effects on natural killer T cell function.
Science. 2012 Apr 27;336(6080):489-93. doi: 10.1126/science.1219328. Epub 2012 Mar 22.
9
Regulatory T cells induced by mucosal B cells alleviate allergic airway hypersensitivity.
Am J Respir Cell Mol Biol. 2012 May;46(5):651-9. doi: 10.1165/rcmb.2011-0246OC. Epub 2011 Dec 28.
10
Low diversity of the gut microbiota in infants with atopic eczema.
J Allergy Clin Immunol. 2012 Feb;129(2):434-40, 440.e1-2. doi: 10.1016/j.jaci.2011.10.025. Epub 2011 Dec 6.

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