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藤黄果果皮通过单胺能途径产生的抗抑郁和抗焦虑作用。

Antidepressant and anxiolytic effects of Garcinia indica fruit rind via monoaminergic pathway.

作者信息

Dhamija Isha, Parle Milind, Kumar Sandeep

机构信息

Department of Pharmaceutical Sciences, Guru Jambheshwar University of Sciences and Technology, Hisar, Haryana, India.

Department of Biotechnology, National Institute of Technology, Jalandhar, Punjab, 144011, India.

出版信息

3 Biotech. 2017 Jun;7(2):131. doi: 10.1007/s13205-017-0766-x. Epub 2017 Jun 8.

Abstract

Depression and anxiety are the most crippling neuropsychiatric disorders of this modern era. These mostly occur as anxiety followed by depression or in mixed state. Therefore, there is an urgent need of a safe and effective treatment, which proves its worth in this ailment. What else than a conventional food would be a better choice for a convenient therapy. Therefore, Garcinia indica, commonly known as Kokam, fruit rind has been used in the present study to investigate its antidepressant and anti-anxiety potential using forced swim test, tail suspension test, and reserpine-induced hypothermia; and elevated plus maze, hole-board test, and light dark model, respectively. Garcinia indica fruit rind given to mice with food for consecutive 14 days at 0.5, 1, and 2% w/w significantly (p < 0.05) reduced despair behavior in forced swim test, immobility duration in tail suspension test, and also switched the hypothermia (reserpine induced) to normal temperature significantly (p < 0.05). Garcinia indica significantly (p < 0.05) raised the time elapsed and count of entries in open arms of elevated plus maze, enhanced incidence of head dipping in holes of hole board along with duration of expending time in lit compartment of light dark model, exhibiting its anti-anxiety effect. Garcinia indica significantly reduced monoamine oxidase and malondialdehyde levels providing support to neuroprotective potential of fruit rind. The mechanistic study showed the participation of G. indica at α-adrenoceptor and D-dopamine receptor, by attenuating prazosin and sulpiride-induced increase in immobility duration. Garcinia indica fruit rind showed a significant antidepressant and anxiolytic effect while no effect on locomotor activity, i.e., no psycho-stimulation.

摘要

抑郁症和焦虑症是现代社会中最具致残性的神经精神疾病。这些疾病大多先出现焦虑,随后发展为抑郁,或呈现混合状态。因此,迫切需要一种安全有效的治疗方法,以证明其在这种疾病中的价值。除了传统食物,还有什么比它更适合作为便捷疗法的选择呢?因此,在本研究中使用了通常被称为罗望子的藤黄果果皮,分别通过强迫游泳试验、悬尾试验和利血平诱导的体温过低来研究其抗抑郁和抗焦虑潜力;并分别通过高架十字迷宫试验、洞板试验和明暗箱试验进行研究。连续14天以0.5%、1%和2%(w/w)的剂量将藤黄果果皮与食物一起喂给小鼠,在强迫游泳试验中显著(p<0.05)降低了绝望行为,在悬尾试验中显著减少了不动时间,并且还显著(p<0.05)将体温过低(利血平诱导)恢复到正常体温。藤黄果果皮显著(p<0.05)延长了高架十字迷宫开放臂中的停留时间和进入次数,增加了洞板试验中探头次数,并延长了明暗箱试验中在亮区的停留时间,显示出其抗焦虑作用。藤黄果果皮显著降低了单胺氧化酶和丙二醛水平,为果皮的神经保护潜力提供了支持。机制研究表明,藤黄果通过减弱哌唑嗪和舒必利诱导的不动时间增加,参与了α-肾上腺素能受体和D-多巴胺受体的作用。藤黄果果皮显示出显著的抗抑郁和抗焦虑作用,而对运动活性没有影响,即没有精神兴奋作用。

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