Hirashima Tsuyoshi, Rens Elisabeth G, Merks Roeland M H
Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Kawahara, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
Centrum Wiskunde & Informatica, Life Sciences Group, Science Park 123, 1098, XG, Amsterdam, the Netherlands.
Dev Growth Differ. 2017 Jun;59(5):329-339. doi: 10.1111/dgd.12358. Epub 2017 Jun 8.
Mathematical modeling is an essential approach for the understanding of complex multicellular behaviors in tissue morphogenesis. Here, we review the cellular Potts model (CPM; also known as the Glazier-Graner-Hogeweg model), an effective computational modeling framework. We discuss its usability for modeling complex developmental phenomena by examining four fundamental examples of tissue morphogenesis: (i) cell sorting, (ii) cyst formation, (iii) tube morphogenesis in kidney development, and (iv) blood vessel formation. The review provides an introduction for biologists for starting simulation analysis using the CPM framework.
数学建模是理解组织形态发生中复杂多细胞行为的重要方法。在此，我们回顾细胞Potts模型（CPM；也称为Glazier-Graner-Hogeweg模型），这是一个有效的计算建模框架。我们通过研究组织形态发生的四个基本例子来讨论其对复杂发育现象建模的适用性：（i）细胞分选，（ii）囊肿形成，（iii）肾脏发育中的管状形态发生，以及（iv）血管形成。本综述为生物学家提供了使用CPM框架开始模拟分析的介绍。
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