Thomas Tonya N, Siff Lauren N, Jelovsek J Eric, Barber Matthew
Obstetrics, Gynecology and Women's Health Institute, Cleveland Clinic, Cleveland, Ohio.
Obstet Gynecol. 2017 Jul;130(1):118-125. doi: 10.1097/AOG.0000000000002068.
To compare prevalence and severity of any surgical pain between transobturator and retropubic slings; secondary aims were to compare pain at anatomic locations, pain medication use, and pain resolution between transobturator and retropubic slings and to compare pain between types of transobturator slings.
This is a secondary analysis of the Trial of Mid-Urethral Slings, which compared retropubic and transobturator sling outcomes and included 597 participants from 2006 to 2008. Postoperative assessments included body maps, visual analog scales, Surgical Pain Scales, and medication inventories for 30 days, at 6 weeks, and 6, 12, and 24 months. Postoperative pain prevalence and severity were compared. Mixed models compared pain resolution and severity over time. Regression models compared pain prevalence and severity between types of transobturator slings. Eighty percent power was provided for the primary outcome pain prevalence and 95% power was provided for the primary outcome pain severity.
Postoperative prevalence of any surgical pain, pain severity, and pain medication was not different between retropubic and transobturator slings. Retropubic sling was associated with greater prevalence of suprapubic pain at 2 weeks (proportion difference 10.6%; 95% confidence interval [CI] 4.6-16.4%; P<.001). Transobturator sling was associated with greater prevalence of groin pain at 2 weeks (proportion difference 12.0%; 95% CI 7.1-16.8%; P<.001). There was no difference in pain resolution (odds ratio [OR] 1.11, 95% CI 0.88-1.40; P=.38). Between types of transobturator slings, the odds of surgical pain were similar at 2 (OR 2.39, 95% CI 0.51-11.31; P=.27) and 6 weeks (OR 0.46, 95% CI 0.02-9.20; P=.61).
Transobturator and retropubic slings are associated with low prevalence of any surgical pain. Transobturator sling was associated with greater prevalence of groin pain at 2 weeks, and retropubic sling was associated with greater prevalence of suprapubic pain at 2 weeks. Surgical pain resolved quickly in both groups.
比较经闭孔吊带术与耻骨后吊带术的手术疼痛发生率及严重程度;次要目的是比较经闭孔吊带术与耻骨后吊带术在解剖部位的疼痛、止痛药物使用及疼痛缓解情况,并比较不同类型经闭孔吊带术之间的疼痛情况。
这是对尿道中段吊带术试验的二次分析,该试验比较了耻骨后吊带术与经闭孔吊带术的疗效,纳入了2006年至2008年的597名参与者。术后评估包括身体疼痛部位图、视觉模拟量表、手术疼痛量表以及术后30天、6周、6个月、12个月和24个月的用药清单。比较术后疼痛发生率及严重程度。混合模型比较不同时间点的疼痛缓解情况及严重程度。回归模型比较不同类型经闭孔吊带术之间的疼痛发生率及严重程度。主要结局疼痛发生率的检验效能为80%,主要结局疼痛严重程度的检验效能为95%。
耻骨后吊带术与经闭孔吊带术在术后任何手术疼痛的发生率、疼痛严重程度及止痛药物使用方面无差异。耻骨后吊带术在术后2周耻骨上区疼痛发生率更高(比例差异10.6%;95%置信区间[CI]4.6 - 16.4%;P <.001)。经闭孔吊带术在术后2周腹股沟区疼痛发生率更高(比例差异12.0%;95% CI 7.1 - 16.8%;P <.001)。疼痛缓解情况无差异(优势比[OR]1.11,95% CI 0.88 - 1.40;P = 0.38)。不同类型经闭孔吊带术之间,术后2周(OR 2.39,95% CI 0.51 - 11.31;P = 0.27)和6周(OR 0.46,95% CI 0.02 - 9.20;P = 0.61)手术疼痛的几率相似。
经闭孔吊带术和耻骨后吊带术的任何手术疼痛发生率均较低。经闭孔吊带术在术后2周腹股沟区疼痛发生率更高,耻骨后吊带术在术后2周耻骨上区疼痛发生率更高。两组手术疼痛均迅速缓解。