Pavón Natalia, Buelna-Chontal Mabel, Correa Francisco, Yoval-Sánchez Belem, Belmont Javier, Hernández-Esquivel Luz, Rodríguez-Zavala José S, Chávez Edmundo
a Departamento de Farmacología, Instituto Nacional de Cardiología "Ignacio Chávez", México D.F.
b Departamento de Biomedicina Cardiovascular, Instituto Nacional de Cardiología "Ignacio Chávez", México D.F.
Biochem Cell Biol. 2017 Oct;95(5):556-562. doi: 10.1139/bcb-2017-0027. Epub 2017 Jun 8.
In this work, we studied the protective effects of tamoxifen (TAM) on disulfiram (Dis)-induced mitochondrial membrane insult. The results indicate that TAM circumvents the inner membrane leakiness manifested as Ca release, mitochondrial swelling, and collapse of the transmembrane electric gradient. Furthermore, it was found that TAM prevents inactivation of the mitochondrial enzyme aconitase and detachment of cytochrome c from the inner membrane. Interestingly, TAM also inhibited Dis-promoted generation of hydrogen peroxide. Given that TAM is an antioxidant molecule, it is plausible that its protection may be due to the inhibition of Dis-induced oxidative stress.
