Carol Emily E, Spencer Robert L, Mittal Vijay A
University of Colorado Boulder, Department of Psychology and Neuroscience, Center for Neuroscience, Boulder, CO, 80309, United States.
University of Colorado Boulder, Department of Psychology and Neuroscience, Center for Neuroscience, Boulder, CO, 80309, United States.
Psychoneuroendocrinology. 2017 Sep;83:58-64. doi: 10.1016/j.psyneuen.2017.04.017. Epub 2017 May 30.
Recent studies have posited a relationship between cannabis use and the biological stress system, but this critical relationship has not been evaluated during the ultra high-risk (UHR) period immediately preceding the onset of psychotic disorders. Salivary cortisol samples were collected on 46 UHR and 29 control adolescents; these individuals were assessed for current cannabis use with a urine panel and self-report. UHR participants where separated into two groups: Current Cannabis Use (UHR-CU) and No Current Cannabis Use (UHR-NC). Healthy Control participants (HC) were free of cannabis use. Consistent with the literature, results indicate UHR individuals showed elevated cortisol levels when compared to HC participants. Further, we also observed that UHR-CU participants exhibited elevated levels when compared to both the non-using UHR and HC groups. Findings suggest that cannabis use may interact with underlying biological vulnerability associated with the hypothalamic-pituitary-adrenal (HPA) axis system.
近期研究提出了大麻使用与生物应激系统之间的关系，但在精神障碍发作前的超高风险（UHR）期，这一关键关系尚未得到评估。收集了46名超高风险青少年和29名对照青少年的唾液皮质醇样本；通过尿液检测和自我报告对这些个体当前的大麻使用情况进行了评估。超高风险参与者被分为两组：当前使用大麻组（UHR-CU）和当前未使用大麻组（UHR-NC）。健康对照参与者（HC）未使用大麻。与文献一致，结果表明，与健康对照参与者相比，超高风险个体的皮质醇水平升高。此外，我们还观察到，与未使用大麻的超高风险组和健康对照组相比，当前使用大麻的超高风险参与者的皮质醇水平更高。研究结果表明，大麻使用可能与下丘脑-垂体-肾上腺（HPA）轴系统相关的潜在生物易感性相互作用。
