D'Addona Alessio, Maffulli Nicola, Formisano Silvestro, Rosa Donato
Department of Public Health, Section of Orthopaedic and Trauma Surgery, School of Medicine and Surgery, University of Naples "Federico II", Via Pansini 5, 80131, Naples, Italy.
Centre for Sports and Exercise Medicine, Barts and The London School of Medicine and Dentistry, Mile End Hospital, 275 Bancroft Road, London, E1 4DG, England, UK; Department of Musculoskeletal Disorders, Faculty of Medicine and Surgery, University of Salerno, Salerno, Italy.
Surgeon. 2017 Oct;15(5):297-302. doi: 10.1016/j.surge.2017.04.004. Epub 2017 Jun 7.
Pain and functional limitation are frequent in symptomatic tendinopathy. The essential lesion of tendinopathy is a failed healing response. Understanding the cellular and molecular mechanisms involved in a failed healing response during the early stages of pathogenesis of tendinopathy would help to develop new and effective treatments. The role of inflammation in the development of tendon pathologies has been revived during the last few years, in particular during the first phases of tendinopathies, when "early tendinopathy" may not be clinically evident. This review outlines the possible molecular events that occur in the first phases of tendinopathy onset, stressing the role of pro-inflammatory cytokines, proteolytic enzymes, growth factors and healing genes in the development of tendon disorders.
疼痛和功能受限在有症状的肌腱病中很常见。肌腱病的本质病变是愈合反应失败。了解肌腱病发病早期愈合反应失败所涉及的细胞和分子机制，将有助于开发新的有效治疗方法。在过去几年中，炎症在肌腱病变发展中的作用再次受到关注，特别是在肌腱病的最初阶段，此时“早期肌腱病”在临床上可能并不明显。这篇综述概述了肌腱病发病初期可能发生的分子事件，强调了促炎细胞因子、蛋白水解酶、生长因子和愈合基因在肌腱疾病发展中的作用。
