颈动脉斑块与中国脑卒中人群认知障碍的关系：SOS-脑卒中研究。
Association between Carotid Plaque and Cognitive Impairment in Chinese Stroke Population: The SOS-Stroke Study.
机构信息
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
China National Clinical Research Center for Neurological Diseases, Beijing, China.
出版信息
Sci Rep. 2017 Jun 8;7(1):3066. doi: 10.1038/s41598-017-02435-3.
We aimed to investigate the association between carotid plaques and cognitive impairment among patients with acute ischemic stroke, and to assess key clinical implications. In the Acute Ischemic Stroke Study, patients who received a cognitive testing and underwent complete carotid artery ultrasound scans were included. Cognitive function was measured by the mini-mental state examination. The cross-sectional relationships between cognitive impairment and carotid plaques were evaluated using multivariate logistic regression analysis. Of the 3116 patients included in this study, 826 (26.51%) patients were diagnosed with cognitive impairment. After adjusting for potential confounders, patients with ≥2 carotid plaques (odds ratio [OR] = 1.47; 95% confidence interval [CI]: 1.19-1.82), patients with ≥2 number of carotid arteries with plaque (OR = 1.48; 95% CI: 1.19-1.84) and patients with hypoechoic plaque (OR = 2.05; 95% CI: 1.24-3.38) are more likely to have cognitive impairment. In this acute ischemic stroke population, the number of carotid plaques, the number of carotid arteries with plaque and plaque stability are all associated with cognitive impairment.
我们旨在探讨急性缺血性脑卒中患者颈动脉斑块与认知障碍之间的关系，并评估其主要的临床意义。在急性缺血性脑卒中研究中，纳入了接受认知测试和完成颈动脉超声检查的患者。认知功能通过简易精神状态检查进行评估。使用多变量逻辑回归分析评估认知障碍与颈动脉斑块之间的横断面关系。在这项研究中，共纳入了 3116 例患者，其中 826 例（26.51%）患者被诊断为认知障碍。在调整了潜在混杂因素后，≥2 个颈动脉斑块的患者（比值比 [OR] = 1.47；95%置信区间 [CI]：1.19-1.82）、≥2 个有斑块的颈动脉的患者（OR = 1.48；95% CI：1.19-1.84）和低回声斑块的患者（OR = 2.05；95% CI：1.24-3.38）更有可能出现认知障碍。在这个急性缺血性脑卒中人群中，颈动脉斑块数量、有斑块的颈动脉数量和斑块稳定性均与认知障碍相关。
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