Stadnicki A, Kacperek T
Thromb Haemost. 1985 Feb 18;53(1):24-5.
The effect of cimetidine and ranitidine on the fibrinolytic activity in vitro was tested. The inhibition rate of spontaneous lysis rose proportionally to the increasing drug doses. However, a similar effect was obtained with two other drugs of different chemical structures and pharmacological properties. Streptokinase activated fibrinolyse was not affected by either of the drugs at any concentration. Nor was clot formation affected in these experiment conditions. The results of the tests in vitro indicate that inhibition of euglobulin fibrinolysis by H2-receptor antagonists is not specific for these drugs and not connected with their pharmacological properties. It is possible to assume that, during therapeutic use, cimetidine and ranitidine have no antifibrinolytic effect. Possible explanation and relevance of these observations are discussed.
测试了西咪替丁和雷尼替丁对体外纤溶活性的影响。自发溶解的抑制率随药物剂量增加而成比例上升。然而，另外两种化学结构和药理性质不同的药物也有类似效果。链激酶激活的纤溶不受任何浓度的这两种药物影响。在这些实验条件下凝块形成也未受影响。体外试验结果表明，H2受体拮抗剂对优球蛋白纤溶的抑制并非这些药物所特有，也与它们的药理性质无关。可以推测，在治疗应用中，西咪替丁和雷尼替丁没有抗纤溶作用。讨论了这些观察结果的可能解释及相关性。
