[抗组胺药的中枢神经系统活性]
[CNS activity of antihistaminics].
作者信息
Wauquier W
出版信息
Z Hautkr. 1985;60 Suppl 1:23-8.
PMID:2859710
Abstract
All the antihistamines tested, except astemizole, alter the S-W cycle in dogs. The changes are consistent with the well-known, sedative side-effects observed with most agents from this class. Astemizole, however, produced no EEG changes even at 50 times the effective antihistamine dose. This finding supports the clinical observation that the drug does not cause drowsiness or sedation.
摘要
除阿司咪唑外，所有受试抗组胺药均会改变犬的慢波-快波睡眠周期。这些变化与该类大多数药物所观察到的众所周知的镇静副作用一致。然而，即使给予有效抗组胺剂量50倍的阿司咪唑，也未引起脑电图变化。这一发现支持了该药物不会导致嗜睡或镇静的临床观察结果。
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