Li Philip H, Lau Chak-Sing
Division of Rheumatology and Clinical Immunology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, Hong Kong.
Int J Rheum Dis. 2017 May;20(5):523-525. doi: 10.1111/1756-185X.13115. Epub 2017 Jun 8.
Systemic lupus erythematosus (SLE) is a diverse and heterogeneous disease with much variation between different ethnicities. Although more severe and prevalent in non-Caucasian populations, the bulk of evidence regarding 'Asian lupus' had traditionally been extrapolated from studies on patient minorities in the West. Lupus research in Asia has since grown exponentially and now takes a leading role in improving the care for SLE patients worldwide. With recent advances, particularly from studies in population-specific phenotyping, genome-wide association studies, lupus nephritis and innovative treatment modalities, we now have an expanding understanding of both the basic science and clinical management of SLE. Upcoming breakthroughs from growing multi-ethnic cohorts and international collaborations will likely bring further important ramifications for SLE management in the near future.
系统性红斑狼疮（SLE）是一种多样且异质性的疾病，不同种族之间存在很大差异。尽管在非白种人群中更为严重和普遍，但传统上关于“亚洲狼疮”的大部分证据都是从西方对少数族裔患者的研究中推断出来的。此后，亚洲的狼疮研究呈指数级增长，现在在改善全球SLE患者的护理方面发挥着主导作用。随着最近的进展，特别是来自特定人群表型分析、全基因组关联研究、狼疮性肾炎和创新治疗方式的研究，我们现在对SLE的基础科学和临床管理有了更深入的了解。来自不断增加的多民族队列和国际合作的即将到来的突破可能会在不久的将来给SLE管理带来进一步的重要影响。
