Smejkal F, Zelená D, Krepelka J, Vancurová I
Acta Virol. 1985 Jan;29(1):11-8.
The antiviral effect of 3 derivatives of benzo(c)fluorenone against encephalomyocarditis (EMC) and vaccinia viruses in mice was compared with that of tilorone hydrochloride (THCl). All 3 derivatives were effective against either virus following single-dose oral application as well as after 4-times repeated subcutaneous (s.c.) treatment, but following oral administration only the VUFB 14162 derivative exerted an antiviral effect corresponding to that of THCl. After s.c. application, however, VUFB 14162 derivative was less toxic than THCl. Two benzo(c)fluorenone derivatives, namely VUFB 14162 and 13431, induced in mouse sera the levels of interferon (IFN), which production kinetics and hyporeactivity phenomenon were comparable with those induced by THCl. Because no IFN was found following administration of the third VUFB 13371 derivative, its antiviral effect consisted probably in an other than IFN-inducing mechanism.
将苯并(c)芴酮的3种衍生物对小鼠脑心肌炎（EMC）病毒和痘苗病毒的抗病毒作用与盐酸替洛隆（THCl）进行了比较。所有3种衍生物在单剂量口服给药以及4次重复皮下（s.c.）给药后对两种病毒均有效，但仅口服给药时，VUFB 14162衍生物的抗病毒作用与THCl相当。然而，皮下给药后，VUFB 14162衍生物的毒性低于THCl。两种苯并(c)芴酮衍生物，即VUFB 14162和13431，可诱导小鼠血清中的干扰素（IFN）水平，其产生动力学和低反应性现象与THCl诱导的相当。由于第三种VUFB 13371衍生物给药后未发现IFN，其抗病毒作用可能由非IFN诱导机制引起。
