Rabijewski Michał, Papierska Lucyna, Piątkiewicz Paweł
a Department of Internal Diseases Diabetology and Endocrinology , Medical University of Warsaw , Warsaw , Poland.
b Department of Endocrinology , Medical Centre for Postgraduate Education , Warsaw , Poland.
Aging Male. 2017 Sep;20(3):205-213. doi: 10.1080/13685538.2017.1338254. Epub 2017 Jun 9.
Prediabetes (PD) leads to reduced testosterone (T) in males, but the association between the anabolic hormones and bone mineral density (BMD) remains unknown.
We investigated an association between the anabolic hormones and BMD in middle-aged and elderly men with PD.
We investigated 84 prediabetic and 56 control men. Total T (TT), calculated free T (cFT), and dehydroepiandrosterone sulfate (DHEAS) were measured, and BMD was assessed using DXA methods.
Patients with PD had lower TT (p < .001), cFT (p < .005), and DHEAS (p < .02) than control group. BMD values of the lower lumbar spine (p < .02) and total body (p < .05) in prediabetic men were lower than in control group. Lumbar spine BMD correlated with TT (r = 0.376), cFT (r = 0.235), and HbA1c (r = -0.368); femoral neck BMD correlated with TT (r = 0.412) and cFT (r = 0.421). The high lumbar spine and femur neck BMD was associated with high TT, cFT, and low HbA1c, while the high total body BMD with high TT, cFT, and low HbA1c.
The anabolic hormones significantly affect BMD in male with PD, and screening for low BMD is necessary in these patients.
糖尿病前期（PD）会导致男性睾酮（T）水平降低，但合成代谢激素与骨密度（BMD）之间的关联尚不清楚。
我们研究了患有PD的中老年男性合成代谢激素与BMD之间的关联。
我们调查了84名糖尿病前期男性和56名对照男性。测量了总睾酮（TT）、计算游离睾酮（cFT）和硫酸脱氢表雄酮（DHEAS），并使用双能X线吸收法（DXA）评估骨密度。
与对照组相比，PD患者的TT（p < 0.001）、cFT（p < 0.005）和DHEAS（p < 0.02）较低。糖尿病前期男性的腰椎（p < 0.02）和全身（p < 0.05）骨密度值低于对照组。腰椎骨密度与TT（r = 0.376）、cFT（r = 0.235）和糖化血红蛋白（HbA1c）（r = -0.368）相关；股骨颈骨密度与TT（r = 0.412）和cFT（r = 0.421）相关。腰椎和股骨颈骨密度高与TT、cFT高和HbA1c低有关，而全身骨密度高与TT、cFT高和HbA1c低有关。
合成代谢激素对患有PD的男性骨密度有显著影响，这些患者有必要筛查低骨密度。
