阿普唑仑、地西泮与安慰剂治疗门诊焦虑症患者的双盲对照研究
A double-blind comparison of alprazolam, diazepam and placebo in the treatment of anxious out-patients.
作者信息
Davison K, Farquharson R G, Khan M C, Majid A
出版信息
Br J Clin Pharmacol. 1985;19 Suppl 1(Suppl 1):37S-43S. doi: 10.1111/j.1365-2125.1985.tb02741.x.
Abstract
In a double-blind 28-day comparison of alprazolam, diazepam and placebo, alprazolam 1.5-3 mg/day was of equivalent anxiolytic effect to 15-30 mg diazepam/day and there was some evidence of antidepressant activity by alprazolam, but not diazepam, in neurotic depression. No serious side-effects or laboratory abnormalities were encountered.
摘要
在一项为期28天的阿普唑仑、地西泮与安慰剂的双盲对照研究中，阿普唑仑1.5 - 3毫克/天的抗焦虑效果与地西泮15 - 30毫克/天相当，并且有证据表明阿普唑仑对神经症性抑郁有抗抑郁活性，而地西泮没有。未发现严重副作用或实验室异常情况。
相似文献
1
A double-blind comparison of alprazolam, diazepam and placebo in the treatment of anxious out-patients.阿普唑仑、地西泮与安慰剂治疗门诊焦虑症患者的双盲对照研究
Br J Clin Pharmacol. 1985;19 Suppl 1(Suppl 1):37S-43S. doi: 10.1111/j.1365-2125.1985.tb02741.x.
2
A double blind comparison of alprazolam, diazepam and placebo in the treatment of anxious out-patients.阿普唑仑、地西泮与安慰剂治疗门诊焦虑症患者的双盲对照研究。
Psychopharmacology (Berl). 1983;80(4):308-10. doi: 10.1007/BF00432110.
3
Anxiolytic efficacy of alprazolam compared to diazepam and placebo.阿普唑仑与地西泮及安慰剂相比的抗焦虑疗效。
J Int Med Res. 1980;8(2):139-43. doi: 10.1177/030006058000800207.
4
A controlled clinical trial of alprazolam for the treatment of anxiety.阿普唑仑治疗焦虑症的对照临床试验。
Am J Psychiatry. 1983 Jan;140(1):82-5. doi: 10.1176/ajp.140.1.82.
5
Multicenter double-blind efficacy and safety study comparing alprazolam, diazepam and placebo in clinically anxious patients.一项多中心双盲疗效与安全性研究，比较阿普唑仑、地西泮与安慰剂在临床焦虑症患者中的效果。
J Clin Psychiatry. 1981 Sep;42(9):347-51.
6
Alprazolam compared to diazepam and placebo in the treatment of anxiety.阿普唑仑与地西泮和安慰剂在焦虑症治疗中的比较。
J Clin Psychiatry. 1980 Jul;41(7):245-8.
7
Alprazolam in the treatment of generalized anxiety and panic disorders: a double-blind placebo-controlled study.阿普唑仑治疗广泛性焦虑症和惊恐障碍：一项双盲安慰剂对照研究。
Psychopharmacology (Berl). 1982;77(3):229-33. doi: 10.1007/BF00464571.
8
Double-blind study of metaclazepam versus diazepam treatment of outpatients with anxiety syndrome.间环西泮与地西泮治疗门诊焦虑综合征的双盲研究。
Pharmacopsychiatry. 1989 May;22(3):120-5. doi: 10.1055/s-2007-1014593.
9
Alprazolam in the treatment of neurotic anxiety.阿普唑仑治疗神经症性焦虑
Pharmatherapeutica. 1983;3(7):451-5.
10
Alprazolam and diazepam in the treatment of generalized anxiety.阿普唑仑和地西泮治疗广泛性焦虑症
J Clin Psychopharmacol. 1984 Jun;4(3):125-9.
引用本文的文献
1
Clinical pharmacology, clinical efficacy, and behavioral toxicity of alprazolam: a review of the literature.阿普唑仑的临床药理学、临床疗效及行为毒性：文献综述
CNS Drug Rev. 2004 Spring;10(1):45-76. doi: 10.1111/j.1527-3458.2004.tb00003.x.
2
The effects of triazolobenzodiazepines in two animal tests of anxiety and in the holeboard.三唑并苯二氮䓬类药物在两项动物焦虑试验及跳台试验中的作用。
Br J Pharmacol. 1985 Nov;86(3):729-35. doi: 10.1111/j.1476-5381.1985.tb08952.x.
本文引用的文献
1
A rating scale for depression.一种抑郁症评定量表。
J Neurol Neurosurg Psychiatry. 1960 Feb;23(1):56-62. doi: 10.1136/jnnp.23.1.56.
2
The assessment of anxiety states by rating.通过评分对焦虑状态进行评估。
Br J Med Psychol. 1959;32(1):50-5. doi: 10.1111/j.2044-8341.1959.tb00467.x.
3
Alprazolam compared to diazepam and placebo in the treatment of anxiety.阿普唑仑与地西泮和安慰剂在焦虑症治疗中的比较。
J Clin Psychiatry. 1980 Jul;41(7):245-8.
4
Multicenter double-blind efficacy and safety study comparing alprazolam, diazepam and placebo in clinically anxious patients.一项多中心双盲疗效与安全性研究，比较阿普唑仑、地西泮与安慰剂在临床焦虑症患者中的效果。
J Clin Psychiatry. 1981 Sep;42(9):347-51.
5
Anxiolytic efficacy of alprazolam compared to diazepam and placebo.阿普唑仑与地西泮及安慰剂相比的抗焦虑疗效。
J Int Med Res. 1980;8(2):139-43. doi: 10.1177/030006058000800207.
6
Pilot open label study with alprazolam (U31, 889) in outpatients with neurotic depression.阿普唑仑（U31, 889）用于门诊神经症性抑郁症患者的开放性试验研究。
Curr Ther Res Clin Exp. 1976 Jun;19(6):661-8.
Zotero 插件