评估癌症厌食症的病理生理学。
Assessing pathophysiology of cancer anorexia.
机构信息
aDepartment of Clinical Medicine bDepartment of Clinical and Molecular Medicine, Sapienza University, Rome, Italy cCancer Metabolism Research Group, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.
出版信息
Curr Opin Clin Nutr Metab Care. 2017 Sep;20(5):340-345. doi: 10.1097/MCO.0000000000000394.
PURPOSE OF REVIEW
Cancer anorexia is a negative prognostic factor and is broadly defined as the loss of the interest in food. However, multiple clinical domains contribute to the phenotype of cancer anorexia. The characterization of the clinical and molecular pathophysiology of cancer anorexia may enhance the efficacy of preventive and therapeutic strategies.
RECENT FINDINGS
Clinical trials showed that cancer anorexia should be considered as an umbrella encompassing different signs and symptoms contributing to appetite disruption in cancer patients. Loss of appetite, early satiety, changes in taste and smell are determinants of cancer anorexia, whose presence should be assessed in cancer patients. Interestingly, neuronal correlates of cancer anorexia-related symptoms have been revealed by brain imaging techniques.
SUMMARY
The pathophysiology of cancer anorexia is complex and involves different domains influencing eating behavior. Limiting the assessment of cancer anorexia to questions investigating changes in appetite may impede correct identification of the targets to address.
综述目的
癌症厌食是一种负面预后因素，广义上被定义为对食物兴趣的丧失。然而，多个临床领域都与癌症厌食的表型有关。对癌症厌食的临床和分子病理生理学进行特征描述可能会提高预防和治疗策略的疗效。
最新发现
临床试验表明，癌症厌食应被视为一个涵盖导致癌症患者食欲紊乱的不同体征和症状的总称。食欲不振、早饱、味觉和嗅觉改变是癌症厌食的决定因素，应在癌症患者中评估这些因素的存在情况。有趣的是，脑成像技术已经揭示了与癌症厌食相关症状的神经关联。
总结
癌症厌食的病理生理学很复杂，涉及影响饮食行为的不同领域。将癌症厌食的评估局限于调查食欲变化的问题可能会妨碍对需要解决的目标的正确识别。
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