非畸形单胎婴儿按胎龄出生体重划分的婴儿死亡率及死因：一项基于2002 - 2012年人群的研究。

Infant mortality and causes of death by birth weight for gestational age in non-malformed singleton infants: a 2002-2012 population-based study.

作者信息

Premru-Srsen Tanja, Verdenik Ivan, Ponikvar Barbara Mihevc, Steblovnik Lili, Geršak Ksenija, Cerar Lilijana Kornhauser

机构信息

Department of Perinatology, Division of Obstetrics and Gynecology, University Medical Centre Ljubljana, Ljubljana, Slovenia.

National Institute of Public Health, Ljubljana, Slovenia.

出版信息

J Perinat Med. 2018 Jul 26;46(5):547-553. doi: 10.1515/jpm-2017-0103.

DOI:10.1515/jpm-2017-0103

PMID:28599397

Abstract

OBJECTIVE

To explore the associations between birth weight for gestational age (GA) and infant mortality as well as causes of infant death.

STUDY DESIGN

A population-based observational study conducted between 2002 and 2012 included 203,620 non-malformed singleton live births from Slovenia. Poisson regression analyses were performed to estimate the crude relative risk (RR) and adjusted RR (aRR) for infant mortality by birth weight percentiles stratified by the GA subgroups term, moderate-to-late preterm, very preterm and extremely preterm.

RESULTS

Compared with appropriate for GA (AGA) term infants (referent-AGA), infant mortality was significantly higher in small for GA (SGA) term infants [aRR=2.79 (1.41-5.50)], with significant cause-specific infant mortality risk for neuromuscular disorders [RR=10.48 (2.62-41.91)]. The differences in infant mortality and cause-specific infant mortality in preterm subgroups between referent-AGA and SGA were insignificant.

CONCLUSIONS

In the Slovenian population, birth weight for GA is significantly associated with infant mortality only in infants born at term.

摘要

目的

探讨孕周别出生体重与婴儿死亡率以及婴儿死亡原因之间的关联。

研究设计

一项基于人群的观察性研究，于2002年至2012年期间进行，纳入了来自斯洛文尼亚的203,620例非畸形单胎活产婴儿。通过泊松回归分析，按孕周亚组（足月儿、中晚期早产儿、极早产儿和超早产儿）分层的出生体重百分位数，估计婴儿死亡率的粗相对风险（RR）和调整后RR（aRR）。

结果

与适于孕周（AGA）足月儿（参照-AGA）相比，小于孕周（SGA）足月儿的婴儿死亡率显著更高[aRR = 2.79（1.41 - 5.50）]，神经肌肉疾病的婴儿特定病因死亡风险显著[RR = 10.48（2.62 - 41.91）]。参照-AGA和SGA之间早产儿亚组的婴儿死亡率及婴儿特定病因死亡率差异不显著。