[Nle4，D-Phe7]-α-促黑素：一种对脊椎动物色素细胞有长效作用的超强促黑素。

[Nle4, D-Phe7]-alpha-MSH: a superpotent melanotropin with prolonged action on vertebrate chromatophores.

作者信息

Hadley M E, Mieyr J H, Martin B E, Castrucci A M, Hruby V J, Sawyer T K, Powers E A, Rao K R

出版信息

Comp Biochem Physiol A Comp Physiol. 1985;81(1):1-6. doi: 10.1016/0300-9629(85)90259-2.

Abstract

The in vitro and in vivo responses of integumental chromatophores to alpha-MSH and a related analogue, [Nle4, D-Phe7] -alpha-MSH, were studied in a number of vertebrate species: the teleost, Lebistes reticulatus; the amphibians, Rana pipiens, R. catesbeiana, Xenopus laevis, Bufo alvarius, and B. cognatus; the lizard, Anolis carolinensis; the rattlesnake, Crotalus atrox. The alpha-melanotropin analogue was a superpotent agonist in the in vitro frog (R. pipiens, R. catesbeiana) and lizard (A. carolinensis) skin bioassays. In all species studied, the analogue exhibited ultraprolonged melanotropic activity, both in vitro and in vivo. This melanotropin and related analogues should prove useful in the study of numerous physiological processes, particularly when prolonged melanotropic activity is desired.

摘要

在多种脊椎动物中研究了体表色素细胞对α-促黑素（α-MSH）和一种相关类似物[Nle4, D-Phe7]-α-MSH的体外和体内反应，这些动物包括：硬骨鱼，虹鳉；两栖动物，豹蛙、牛蛙、非洲爪蟾、绿蟾蜍和科氏蟾蜍；蜥蜴，卡罗来纳安乐蜥；响尾蛇，变色矛头蝮。在体外青蛙（豹蛙、牛蛙）和蜥蜴（卡罗来纳安乐蜥）皮肤生物测定中，α-促黑素类似物是一种超强效激动剂。在所有研究的物种中，该类似物在体外和体内均表现出超长效的促黑素活性。这种促黑素及相关类似物在众多生理过程的研究中应会证明是有用的，特别是在需要长效促黑素活性时。