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脊髓脊膜膨出患者产前与产后管理的比较

Comparison of Prenatal and Postnatal Management of Patients with Myelomeningocele.

作者信息

Cavalheiro Sergio, da Costa Marcos Devanir Silva, Moron Antonio Fernandes, Leonard Jeffrey

机构信息

Neurosurgery Department, Federal University of São Paulo-UNIFESP, Rua Pedro de Toledo, 715, 6th Floor, São Paulo, São Paulo 04024-001, Brazil.

Neurosurgery Department, Federal University of São Paulo-UNIFESP, Rua Pedro de Toledo, 715, 6th Floor, São Paulo, São Paulo 04024-001, Brazil; Department of Pediatric Neurosurgery, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.

出版信息

Neurosurg Clin N Am. 2017 Jul;28(3):439-448. doi: 10.1016/j.nec.2017.02.005. Epub 2017 Mar 24.

Abstract

Myelomeningocele (MMC) is a costly lifetime disease with many comorbidities, including sensory and motor lower limb disability, bladder/bowel dysfunction, scoliosis, club foot, and hydrocephalus. MMC treatment options have changed over time because routine use of fetal ultrasonography and MRI has provided prenatal diagnosis and the potential for fetal surgery. There is still no consensus on how to treat the MMC diagnoses prenatally, mainly related to the infrastructure required to operate on pregnant patients. This article provides an overview of prenatal and postnatal MMC repair and the features in the prenatal diagnosis.

摘要

脊髓脊膜膨出(MMC)是一种需要高昂终生治疗费用的疾病,伴有多种合并症,包括下肢感觉和运动功能障碍、膀胱/肠道功能障碍、脊柱侧弯、马蹄内翻足和脑积水。随着时间的推移,MMC的治疗选择发生了变化,因为胎儿超声检查和MRI的常规使用实现了产前诊断以及胎儿手术的可能性。对于如何在产前治疗MMC诊断尚无共识,这主要与为孕妇进行手术所需的基础设施有关。本文概述了产前和产后MMC修复以及产前诊断的特点。

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