Szabo S, Reichlin S
Fed Proc. 1985 Jun;44(9):2540-5.
Cysteamine (CSH) and its close derivatives deplete immunoreactive somatostatin (SS) in rat organs. The effect of CSH is dose and time dependent and reversible. Structural requirements of the analogs are the presence of either -SH or -NH2 on a two- or three-carbon alkyl molecule; both radicals together increase, whereas insertion of carboxyl abolishes potency. The duodenal ulcerogenic potency of CSH derivatives is correlated significantly with their SS-depleting activity in the gastric mucosa. The mechanism of this action of CSH is poorly understood, but it is not caused by increased release, enhanced degradation of the peptide, or selective necrosis of SS cells. It is likely that in the intracellular environment CSH causes a conformational change in the peptide that affects the antigenic and functional properties of SS.
半胱胺（CSH）及其密切相关的衍生物可使大鼠器官中的免疫反应性生长抑素（SS）减少。CSH的作用具有剂量和时间依赖性，且是可逆的。类似物的结构要求是在二碳或三碳烷基分子上存在-SH或-NH2；两个基团同时存在会增强活性，而插入羧基则会消除效力。CSH衍生物的十二指肠致溃疡效力与其在胃黏膜中的SS耗竭活性显著相关。CSH这种作用的机制尚不清楚，但它不是由肽的释放增加、降解增强或SS细胞的选择性坏死引起的。在细胞内环境中，CSH可能会导致肽的构象变化，从而影响SS的抗原性和功能特性。
