幽门螺杆菌不会将半胱胺释放到胃液中。
Helicobacter pylori does not release cysteamine into gastric juice.
作者信息
Leonard M B, Neithercut W D, Gillen D, McColl K E
机构信息
Department of Chemical Pathology, Wirral Hospital NHS Trust and Medicine, Gardiner Institute, Western Infirmary, Glasgow, UK.
出版信息
J Clin Pathol. 1997 Sep;50(9):769-70. doi: 10.1136/jcp.50.9.769.
AIM
To determine whether Helicobacter pylori releases cysteamine into gastric juice as cysteamine is known to be ulcerogenic.
METHODS
Samples of fasting gastric juice were collected from 22 individuals (four women); 10 subjects were H pylori negative. The presence of infection was confirmed by examination and culture of gastric biopsies. Cysteamine in gastric juice was measured by reversed phase gradient high performance liquid chromatography with a detection limit of 10 mumol/l.
RESULTS
Cysteamine was not detected in any of the gastric juice samples or in extracts of cultured H pylori.
CONCLUSIONS
If H pylori produces cysteamine then the amounts produced are insignificant and are unlikely to explain the association between H pylori infection and the development of duodenal ulcer disease.
目的
已知半胱胺具有致溃疡作用，本研究旨在确定幽门螺杆菌是否会向胃液中释放半胱胺。
方法
收集了22名个体（4名女性）的空腹胃液样本；其中10名受试者幽门螺杆菌检测为阴性。通过胃活检组织检查和培养确认感染情况。采用反相梯度高效液相色谱法测定胃液中的半胱胺，检测限为10 μmol/L。
结果
在任何胃液样本或培养的幽门螺杆菌提取物中均未检测到半胱胺。
结论
如果幽门螺杆菌产生半胱胺，那么产生的量极少，不太可能解释幽门螺杆菌感染与十二指肠溃疡疾病发生之间的关联。
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