Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Neurosciences Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), 75005 Paris, France.
Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Neurosciences Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), 75005 Paris, France.
Neuropharmacology. 2018 Jul 1;136(Pt A):37-45. doi: 10.1016/j.neuropharm.2017.06.006. Epub 2017 Jun 7.
Although the thalamus presents a rather limited repertoire of GABAergic cell types compare to other CNS area, this structure is a privileged system to study how GABA impacts neuronal network excitability. Indeed both glutamatergic thalamocortical (TC) and GABAergic nucleus reticularis thalami (NRT) neurons present a high expression of T-type voltage-dependent Ca channels whose activation that shapes the output of the thalamus critically depends upon a preceding hyperpolarisation. Because of this strict dependence, a tight functional link between GABA mediated hyperpolarization and T-currents characterizes the thalamic network excitability. In this review we summarize a number of studies showing that the relationships between the various thalamic GABA receptors and T-channels are complex and bidirectional. We discuss how this dynamic interaction sets the global intrathalamic network activity and its long-term plasticity and highlight how the functional relationship between GABA release and T-channel-dependent excitability is finely tuned by the T-channel activation itself. Finally, we illustrate how an impaired balance between T-channels and GABA receptors can lead to pathologically abnormal cellular and network behaviours. This article is part of the "Special Issue Dedicated to Norman G. Bowery".
尽管与其他中枢神经系统区域相比，丘脑呈现出相对有限的 GABA 能细胞类型，但该结构是研究 GABA 如何影响神经元网络兴奋性的优先系统。事实上，谷氨酸能丘脑皮质（TC）和 GABA 能丘脑网状核（NRT）神经元都表现出高表达 T 型电压依赖性 Ca 通道，其激活对丘脑的输出具有重要影响，这取决于之前的超极化。由于这种严格的依赖性，GABA 介导的超极化和 T 电流之间的紧密功能联系是丘脑网络兴奋性的特征。在这篇综述中，我们总结了一些研究，表明各种丘脑 GABA 受体和 T 通道之间的关系是复杂和双向的。我们讨论了这种动态相互作用如何设定全局丘脑内网络活动及其长期可塑性，并强调了 GABA 释放和 T 通道依赖性兴奋性之间的功能关系如何通过 T 通道的激活本身进行精细调节。最后，我们说明了 T 通道和 GABA 受体之间平衡的破坏如何导致病理性异常的细胞和网络行为。本文是“专门为 Norman G. Bowery 设立的特刊”的一部分。
