聚维酮碘冲洗对癌性直肠切除术后会阴伤口愈合的影响。

The effect of povidone-iodine irrigation on perineal wound healing following proctectomy for carcinoma.

作者信息

Johnson J N, Croton R S, McGlinchey J J, McLoughlin G A

出版信息

J Hosp Infect. 1985 Mar;6 Suppl A:81-6. doi: 10.1016/s0195-6701(85)80050-5.

Abstract

Fifty-six patients undergoing abdomino-perineal excision of the rectum for carcinoma were randomized to receive twice daily irrigation of the perineal wound with either 1% povidone-iodine (PVP-I) or normal saline for 5 days following surgery. The incidence of perineal wound infection, primary and delayed wound healing and persistent sinus formation was recorded. There was a highly significant reduction in perineal wound infection in the PVP-I group (P less than 0.01) and this was true even if perineal wound contamination had occurred during operation (P less than 0.05). Primary wound healing was significantly improved in the treatment group (P less than 0.02) and this was found also in the presence of contamination (P less than 0.005). There was no significant difference between the treated and control group in the incidence of delayed wound healing and persistent sinus formation.

摘要

56例因直肠癌接受腹会阴联合直肠切除术的患者被随机分为两组，术后5天内，一组患者每天用1%聚维酮碘（PVP-I）冲洗会阴伤口两次，另一组用生理盐水冲洗。记录会阴伤口感染、一期和二期伤口愈合以及持续性窦道形成的发生率。PVP-I组会阴伤口感染率显著降低（P<0.01），即使手术中发生了会阴伤口污染，情况也是如此（P<0.05）。治疗组一期伤口愈合情况显著改善（P<0.02），在有污染的情况下也是如此（P<0.005）。治疗组和对照组在二期伤口愈合和持续性窦道形成的发生率上没有显著差异。