Deng Chuiwen, Li Wenli, Li Jing, Zhang Shulan, Li Yongzhe
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
Department of Rheumatology, China-Japan Friendship Hospital, Beijing, China.
BMJ Open. 2017 Jun 9;7(6):e014843. doi: 10.1136/bmjopen-2016-014843.
To perform a meta-analysis to evaluate the diagnostic performance of the antiglycoprotein-2 (GP2) antibody for Crohn's disease (CD).
Three databases (EMBASE, ISI Web of Knowledge and PubMed) were systematically searched. There were 17 eligible studies included in the meta-analysis. A total of 2439 patients with CD and 3184 controls were involved in these studies. STATA V.11.2 and Meta-DiSc V.1.4 were used to perform the meta-analysis.
The area under the summary receiver operating characteristic curve was 0.68-0.72. The pooled diagnostic sensitivity of the anti-GP2 antibody ranged from 14% to 24%, and the specificity was 96%-98%.
The anti-GP2 antibody is a specific biomarker for CD, and further exploration of its prevalence among different clinical phenotypes of CD will provide a better understanding of its diagnostic performance.
进行一项荟萃分析，以评估抗糖蛋白2（GP2）抗体对克罗恩病（CD）的诊断效能。
系统检索了三个数据库（EMBASE、ISI 知识网络和 PubMed）。荟萃分析纳入了17项符合条件的研究。这些研究共涉及2439例克罗恩病患者和3184例对照。使用STATA V.11.2和Meta-DiSc V.1.4进行荟萃分析。
汇总的受试者工作特征曲线下面积为0.68 - 0.72。抗GP2抗体的合并诊断敏感性为14%至24%，特异性为96%至98%。
抗GP2抗体是克罗恩病的一种特异性生物标志物，进一步探索其在克罗恩病不同临床表型中的患病率将有助于更好地理解其诊断效能。
