唾液抗酚糖脂-1 IgM可能表明16岁以下年轻人中存在麻风分枝杆菌的活跃传播。

Salivary anti-PGL-1 IgM may indicate active transmission of Mycobacterium leprae among young people under 16 years of age.

作者信息

Macedo Alexandre Casimiro de, Cunha José Evandro, Yaochite Juliana Navarro Ueda, Tavares Clodis Maria, Nagao-Dias Aparecida Tiemi

机构信息

Universidade Federal do Ceará (UFC), Faculdade de Farmácia, Departamento de Análises Clínicas e Toxicológicas, Fortaleza, CE, Brazil.

Universidade Federal de Alagoas, Faculdade de Enfermagem e Farmácia (ESENFAR), Maceio, AL, Brazil.

出版信息

Braz J Infect Dis. 2017 Sep-Oct;21(5):557-561. doi: 10.1016/j.bjid.2017.05.001. Epub 2017 Jun 9.

DOI:10.1016/j.bjid.2017.05.001

PMID:28602616

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9425475/

Abstract

Considering that the main route of Mycobacterium leprae transmission is the upper respiratory tract, detection of salivary antibodies can be a useful tool for diagnosing early infection. The study aimed to analyze salivary anti-PGL-1 IgA and IgM antibodies in 169 children aged 4-16 years old, who lived nearby or inside the house of multibacillary or paucibacillary leprosy patients in two endemic cities in Alagoas State - Brazil. Salivary anti-PGL-1 antibodies were quantified by modified ELISA method. The frequency of contact and clinical form of the index case were significantly associated with salivary antibody levels. High frequency of IgM positivity strongly suggests active transmission of M. leprae in these communities. We suggest in the present work that salivary anti-PGL IgA and IgM are important biomarkers to be used for identifying communities with probable active transmission of M. leprae.

摘要

鉴于麻风分枝杆菌的主要传播途径是上呼吸道，检测唾液抗体可能是诊断早期感染的有用工具。该研究旨在分析169名4至16岁儿童的唾液抗酚糖脂-1 IgA和IgM抗体，这些儿童居住在巴西阿拉戈斯州两个麻风流行城市中多菌型或少菌型麻风患者房屋附近或屋内。采用改良ELISA法对唾液抗酚糖脂-1抗体进行定量。接触频率和索引病例的临床类型与唾液抗体水平显著相关。IgM阳性的高频率强烈提示这些社区中麻风分枝杆菌的活跃传播。我们在本研究中表明，唾液抗酚糖脂IgA和IgM是用于识别可能存在麻风分枝杆菌活跃传播社区的重要生物标志物。