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1
Recent Laboratory Advances in Diagnostics and Monitoring Response to Treatment in Leprosy.麻风病诊断及治疗反应监测的近期实验室进展
Indian Dermatol Online J. 2019 Mar-Apr;10(2):106-114. doi: 10.4103/idoj.IDOJ_260_18.
2
Challenges and advances in serological and molecular tests to aid leprosy diagnosis.血清学和分子检测在麻风病诊断中的挑战和进展。
Exp Biol Med (Maywood). 2023 Nov;248(22):2083-2094. doi: 10.1177/15353702231209422. Epub 2023 Dec 7.
3
Challenges in the post genomic era for the development of tests for leprosy diagnosis.后基因组时代麻风病诊断检测方法开发面临的挑战。
Rev Soc Bras Med Trop. 2008;41 Suppl 2:89-94. doi: 10.1590/s0037-86822008000700018.
4
Detection and Monitoring of Infection in Nine Banded Armadillos () Using a Quantitative Rapid Test.使用定量快速检测法对九带犰狳感染情况的检测与监测
Front Microbiol. 2021 Oct 28;12:763289. doi: 10.3389/fmicb.2021.763289. eCollection 2021.
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[The refinement of leprosy PCR diagnostics by the amplification of specie-specific repeated fragment of the Mycobacterium leprae genome.].[通过扩增麻风分枝杆菌基因组的物种特异性重复片段来改进麻风病PCR诊断方法。]
Klin Lab Diagn. 2018;63(8):511-516. doi: 10.18821/0869-2084-2018-63-8-511-516.
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Specialized active leprosy search strategies in an endemic area of the Brazilian Amazon identifies a hypermutated strain causing primary drug resistance.在巴西亚马逊河的麻风病流行地区采用专门的主动搜索策略，发现了一种导致原发性耐药的高度变异菌株。
Front Med (Lausanne). 2023 Sep 13;10:1243571. doi: 10.3389/fmed.2023.1243571. eCollection 2023.
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Host immune responses induced by specific Mycobacterium leprae antigens in an overnight whole-blood assay correlate with the diagnosis of paucibacillary leprosy patients in China.在 overnight whole-blood assay 中，由特定的麻风分枝杆菌抗原诱导的宿主免疫反应与中国少菌型麻风患者的诊断相关。
PLoS Negl Trop Dis. 2019 Apr 24;13(4):e0007318. doi: 10.1371/journal.pntd.0007318. eCollection 2019 Apr.
8
Spatial and temporal epidemiology of Mycobacterium leprae infection among leprosy patients and household contacts of an endemic region in Southeast Brazil.巴西东南部麻风病流行地区麻风病患者及其家庭接触者中麻风分枝杆菌感染的时空流行病学研究
Acta Trop. 2016 Nov;163:38-45. doi: 10.1016/j.actatropica.2016.07.019. Epub 2016 Jul 25.
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Nasal PCR assay for the detection of Mycobacterium leprae pra gene to study subclinical infection in a community.用于检测麻风分枝杆菌pra基因的鼻腔聚合酶链反应检测法，以研究社区中的亚临床感染情况。
Microb Pathog. 2017 Mar;104:336-339. doi: 10.1016/j.micpath.2017.01.046. Epub 2017 Jan 27.
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Development of a combined RLEP/16S rRNA (RT) qPCR assay for the detection of viable M. leprae from nasal swab samples.建立一种联合 RLEP/16S rRNA（RT）qPCR 检测方法，用于从鼻拭子样本中检测活的麻风分枝杆菌。
BMC Infect Dis. 2019 Aug 28;19(1):753. doi: 10.1186/s12879-019-4349-9.

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Fluorescent Microscopy: A Useful and Adjunct Tool in Leprosy Diagnosis: A Cross Sectional Study.荧光显微镜检查：麻风病诊断中的一种有用辅助工具：一项横断面研究
Iran J Pathol. 2025;20(1):33-41. doi: 10.30699/ijp.2024.2023590.3263. Epub 2025 Jan 10.
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New cases of childhood leprosy in two male siblings in low endemic province: an iceberg phenomenon?低流行省份两名男性同胞儿童患麻风病新病例：一种冰山现象？
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Highly sensitive and rapid determination of Mycobacterium leprae based on real-time multiple cross displacement amplification.基于实时多重交叉置换扩增的麻风分枝杆菌高灵敏快速检测
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Leprosy: A Review of Epidemiology, Clinical Diagnosis, and Management.麻风病：流行病学、临床诊断与管理综述
J Trop Med. 2022 Jul 4;2022:8652062. doi: 10.1155/2022/8652062. eCollection 2022.
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Algorithm Design for a Cytokine Release Assay of Antigen-Specific In Vitro Stimuli of Circulating Leukocytes to Classify Leprosy Patients and Household Contacts.用于循环白细胞抗原特异性体外刺激的细胞因子释放测定以对麻风病患者和家庭接触者进行分类的算法设计
Open Forum Infect Dis. 2022 Jan 30;9(3):ofac036. doi: 10.1093/ofid/ofac036. eCollection 2022 Mar.
6
Development of a Loop-mediated isothermal amplification (LAMP) technique for specific and early detection of Mycobacterium leprae in clinical samples.建立环介导等温扩增（LAMP）技术，用于临床样本中麻风分枝杆菌的特异性和早期检测。
Sci Rep. 2021 May 10;11(1):9859. doi: 10.1038/s41598-021-89304-2.
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Insights into Proteomics and Biomarkers-An Overview.蛋白质组学与生物标志物洞察——概述
Proteomes. 2021 Jan 29;9(1):7. doi: 10.3390/proteomes9010007.

本文引用的文献

1
-Specific Antibodies in Multibacillary Leprosy Patients Decrease During and After Treatment With Either the Regular 12 Doses Multidrug Therapy (MDT) or the Uniform 6 Doses MDT.多菌型麻风病患者在接受常规 12 剂量联合化疗（MDT）或统一 6 剂量 MDT 治疗期间和治疗后，特异性抗体减少。
Front Immunol. 2018 May 14;9:915. doi: 10.3389/fimmu.2018.00915. eCollection 2018.
2
Antimicrobial resistance in leprosy: results of the first prospective open survey conducted by a WHO surveillance network for the period 2009-15.麻风分枝杆菌耐药性：2009-2015 年世卫组织监测网络开展的首次前瞻性开放性调查结果。
Clin Microbiol Infect. 2018 Dec;24(12):1305-1310. doi: 10.1016/j.cmi.2018.02.022. Epub 2018 Mar 1.
3
Salivary anti-PGL-1 IgM may indicate active transmission of Mycobacterium leprae among young people under 16 years of age.唾液抗酚糖脂-1 IgM可能表明16岁以下年轻人中存在麻风分枝杆菌的活跃传播。
Braz J Infect Dis. 2017 Sep-Oct;21(5):557-561. doi: 10.1016/j.bjid.2017.05.001. Epub 2017 Jun 9.
4
Evaluation of Polymerase Chain Reaction (PCR) with Slit Skin Smear Examination (SSS) to Confirm Clinical Diagnosis of Leprosy in Eastern Nepal.尼泊尔东部采用聚合酶链反应（PCR）与皮肤涂片检查（SSS）评估以确诊麻风病临床诊断的研究
PLoS Negl Trop Dis. 2016 Dec 27;10(12):e0005220. doi: 10.1371/journal.pntd.0005220. eCollection 2016 Dec.
5
Comparative evaluation of PCR amplification of RLEP, 16S rRNA, rpoT and Sod A gene targets for detection of M. leprae DNA from clinical and environmental samples.用于从临床和环境样本中检测麻风分枝杆菌DNA的RLEP、16S rRNA、rpoT和Sod A基因靶点的PCR扩增的比较评估。
Int J Mycobacteriol. 2015 Mar;4(1):54-9. doi: 10.1016/j.ijmyco.2014.11.062. Epub 2015 Jan 23.
6
Antigen-specific assessment of the immunological status of various groups in a leprosy endemic region.麻风病流行地区不同群体免疫状态的抗原特异性评估。
BMC Infect Dis. 2015 May 30;15:218. doi: 10.1186/s12879-015-0962-4.
7
Drug resistance patterns in Mycobacterium leprae isolates from relapsed leprosy patients attending The Leprosy Mission (TLM) Hospitals in India.印度麻风病传教士协会（TLM）医院收治的复发型麻风病患者中麻风分枝杆菌分离株的耐药模式。
Lepr Rev. 2014 Sep;85(3):177-85.
8
Development of a quantitative rapid diagnostic test for multibacillary leprosy using smart phone technology.利用智能手机技术开发用于多菌型麻风病的定量快速诊断测试。
BMC Infect Dis. 2013 Oct 23;13:497. doi: 10.1186/1471-2334-13-497.
9
Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I.中国应用 LID-1 和 PGL-I 连续抗体分析早期发现麻风病。
J Trop Med. 2013;2013:352689. doi: 10.1155/2013/352689. Epub 2013 Jan 28.
10
Cohort study of the seasonal effect on nasal carriage and the presence of Mycobacterium leprae in an endemic area in the general population.在一个流行地区的普通人群中，对鼻腔携带和麻风分枝杆菌存在的季节性影响进行队列研究。
Clin Microbiol Infect. 2013 Oct;19(10):970-4. doi: 10.1111/1469-0691.12087. Epub 2013 Jan 18.

麻风病诊断及治疗反应监测的近期实验室进展

Recent Laboratory Advances in Diagnostics and Monitoring Response to Treatment in Leprosy.

作者信息

Sengupta Utpal

机构信息

Departemnt of Microbiology and Immunology, Stanley Browne Laboratory, TLM Community Hospital, Nand Nagri, New Delhi, India.

出版信息

Indian Dermatol Online J. 2019 Mar-Apr;10(2):106-114. doi: 10.4103/idoj.IDOJ_260_18.

DOI:10.4103/idoj.IDOJ_260_18
PMID:30984583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6434766/
Abstract

The present review briefly summarizes the highlights of the recent advances in -specific tests for early diagnosis of leprosy. In addition to establishing the diagnosis of clinical cases of leprosy, these tests have also been used to detect subclinical infections in endemic population. Several attempts have been made from 1980 onward for standardization of specific diagnostic assays for early detection of leprosy. Brief account about the development and use of these assays has been described in this review article.

摘要

本综述简要总结了麻风病早期诊断特异性检测的最新进展要点。除了用于确诊麻风病临床病例外，这些检测还被用于检测流行地区人群中的亚临床感染。自1980年以来，人们多次尝试对麻风病早期检测的特异性诊断方法进行标准化。本文综述了这些检测方法的发展和应用情况。