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Morphine-6-glucuronide, an important metabolite.

作者信息

Joel S P, Osborne R J, Nixon N S, Slevin M L

出版信息

Lancet. 1985 May 11;1(8437):1099-100. doi: 10.1016/s0140-6736(85)92397-9.

DOI:10.1016/s0140-6736(85)92397-9
PMID:2860309
Abstract
摘要

相似文献

1
Morphine-6-glucuronide, an important metabolite.吗啡-6-葡萄糖醛酸，一种重要的代谢物。
Lancet. 1985 May 11;1(8437):1099-100. doi: 10.1016/s0140-6736(85)92397-9.
2
Morphine and metabolite behavior after different routes of morphine administration: demonstration of the importance of the active metabolite morphine-6-glucuronide.
Clin Pharmacol Ther. 1990 Jan;47(1):12-9. doi: 10.1038/clpt.1990.2.
3
High-performance liquid chromatographic determination of morphine, morphine-3-glucuronide, morphine-6-glucuronide and codeine in biological samples using multi-wavelength forward optical detection: a reply.
J Chromatogr. 1992 Jul 24;578(2):333-4; discussion 335-6. doi: 10.1016/0378-4347(92)80435-s.
4
Increased margin of safety of morphine-6-glucuronide relative to morphine.吗啡-6-葡萄糖醛酸相对于吗啡的安全边际增加。
Anesthesiology. 2004 Jun;100(6):1622; author reply 1622-3. doi: 10.1097/00000542-200406000-00048.
5
The metabolite morphine-6-glucuronide contributes to the analgesia produced by morphine infusion in patients with pain and normal renal function.代谢产物吗啡-6-葡萄糖醛酸苷对疼痛患者且肾功能正常者静脉输注吗啡产生的镇痛作用有贡献。
Clin Pharmacol Ther. 1992 Apr;51(4):422-31. doi: 10.1038/clpt.1992.42.
6
Preliminary pharmacokinetics of morphine and its major metabolites following intravenous administration of four doses to horses.静脉注射四剂吗啡及其主要代谢产物后马的初步药代动力学研究。
J Vet Pharmacol Ther. 2014 Aug;37(4):374-81. doi: 10.1111/jvp.12098. Epub 2014 Jan 31.
7
Morphine 6-glucuronide: a metabolite of morphine with greater emetic potency than morphine in the ferret.吗啡6-葡萄糖醛酸苷：吗啡的一种代谢产物，在雪貂中致吐效力比吗啡更强。
Br J Pharmacol. 1992 May;106(1):3-8. doi: 10.1111/j.1476-5381.1992.tb14284.x.
8
A specific radioimmunoassay for the determination of morphine-6-glucuronide in human plasma.
Ann Clin Biochem. 1995 May;32 ( Pt 3):297-302. doi: 10.1177/000456329503200306.
9
Rethinking the opiate system? Morphine and morphine-6-glucuronide as new endocrine and neuroendocrine mediators.重新审视阿片系统？吗啡和吗啡-6-葡萄糖醛酸苷作为新的内分泌和神经内分泌介质。
Med Sci Monit. 2006 Jun;12(6):SR25-7. Epub 2006 May 29.
10
The pharmacokinetics of morphine and its glucuronide conjugate in a rat model of streptozotocin-induced diabetes and the expression of MRP2, MRP3 and UGT2B1 in the liver.链脲佐菌素诱导糖尿病大鼠模型中吗啡及其葡萄糖醛酸结合物的药代动力学及肝脏中 MRP2、MRP3 和 UGT2B1 的表达。
J Pharm Pharmacol. 2010 Mar;62(3):310-4. doi: 10.1211/jpp.62.03.0004.

引用本文的文献

1
Morphine-6-glucuronide: an analgesic of the future?吗啡-6-葡萄糖醛酸：未来的镇痛药？
Clin Pharmacokinet. 2001;40(7):485-99. doi: 10.2165/00003088-200140070-00001.
2
Sedation in intensive care: morphine and renal function.重症监护中的镇静：吗啡与肾功能
Intensive Care Med. 1986;12(5):359-65. doi: 10.1007/BF00292926.
3
Renal failure does not impair the metabolism of morphine.肾衰竭不会损害吗啡的代谢。
Br J Clin Pharmacol. 1986 Jul;22(1):55-9. doi: 10.1111/j.1365-2125.1986.tb02880.x.
4
Kinetics of morphine in patients with renal failure.肾衰竭患者吗啡的动力学
Eur J Clin Pharmacol. 1987;32(4):377-82. doi: 10.1007/BF00543973.
5
Morphine intoxication in renal failure: the role of morphine-6-glucuronide.肾衰竭中的吗啡中毒：吗啡-6-葡萄糖醛酸的作用
Br Med J (Clin Res Ed). 1986 Jun 14;292(6535):1548-9. doi: 10.1136/bmj.292.6535.1548.
6
Pharmacokinetics of codeine and its metabolites in Caucasian healthy volunteers: comparisons between extensive and poor hydroxylators of debrisoquine.可待因及其代谢产物在高加索健康志愿者体内的药代动力学：异喹胍强代谢型与弱代谢型的比较。
Br J Clin Pharmacol. 1991 Jun;31(6):635-42. doi: 10.1111/j.1365-2125.1991.tb05585.x.
7
Glucuronidation of drugs. A re-evaluation of the pharmacological significance of the conjugates and modulating factors.
Clin Pharmacokinet. 1992 Oct;23(4):292-310. doi: 10.2165/00003088-199223040-00005.