调节性T细胞和叉头框蛋白3作为免疫稳态的调节因子
Regulatory T Cell and Forkhead Box Protein 3 as Modulators of Immune Homeostasis.
作者信息
Pereira Leonn Mendes Soares, Gomes Samara Tatielle Monteiro, Ishak Ricardo, Vallinoto Antonio Carlos Rosário
机构信息
Laboratório de Virologia, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
Programa de Pós-Graduação em Biologia de Agentes Infecciosos e Parasitários, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
出版信息
Front Immunol. 2017 May 26;8:605. doi: 10.3389/fimmu.2017.00605. eCollection 2017.
The transcription factor forkhead box protein 3 (FOXP3) is an essential molecular marker of regulatory T cell (Treg) development in different microenvironments. Tregs are cells specialized in the suppression of inadequate immune responses and the maintenance of homeostatic tolerance. Studies have addressed and elucidated the role played by FOXP3 and Treg in countless autoimmune and infectious diseases as well as in more specific cases, such as cancer. Within this context, the present article reviews aspects of the immunoregulatory profile of FOXP3 and Treg in the management of immune homeostasis, including issues relating to pathology as well as immune tolerance.
转录因子叉头框蛋白3（FOXP3）是不同微环境中调节性T细胞（Treg）发育的关键分子标志物。Tregs是专门负责抑制不适当免疫反应和维持稳态耐受的细胞。已有研究探讨并阐明了FOXP3和Treg在无数自身免疫性疾病、感染性疾病以及更特殊的病例（如癌症）中所起的作用。在此背景下，本文综述了FOXP3和Treg在免疫稳态调控方面的免疫调节特征，包括与病理学以及免疫耐受相关的问题。
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