Chatterjee Arka, White Jeremy S, Hashim Taimoor, Leesar Massoud A
Arka Chatterjee, Taimoor Hashim, Massoud A Leesar, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL 35294, United States.
World J Cardiol. 2017 May 26;9(5):442-447. doi: 10.4330/wjc.v9.i5.442.
To study the relationship of jailed polymer jacketed guide wires (PGW) with procedural myocardial infarction (PMI) after bifurcation coronary interventions.
Consecutive bifurcation interventions performed from January 2010 to October 2014 were included in the study. Chart review was performed to obtain demographic, clinical and procedural data. PMI was defined as Creatine Kinase MB > 3 × upper reference limit of normal. Multivariate logistic regression was used to ascertain relationship of PGW use with PMI.
Two hundred and ninety-three patients (age 63.5 ± 12.3 years; 33.8% diabetic) were included in the study. Eighty point two percent ( = 235) were true bifurcation lesions use of PGW was associated with PMI on univariate analysis (OR = 4.1; = 0.002). This association remained significant after adjusting for other possible risk factors (OR = 3.5; = 0.02).
Our results suggest that PGW use for side branch protection may be associated with PMI. Randomized studies are needed to validate these findings.
研究在冠状动脉分叉病变介入治疗中，使用带聚合物涂层的拘禁导丝（PGW）与术后发生的程序性心肌梗死（PMI）之间的关系。
本研究纳入了2010年1月至2014年10月期间连续进行的分叉病变介入治疗病例。通过查阅病历获取人口统计学、临床和手术相关数据。PMI定义为肌酸激酶同工酶MB>正常上限的3倍。采用多因素逻辑回归分析来确定使用PGW与PMI之间的关系。
293例患者（年龄63.5±12.3岁；33.8%为糖尿病患者）纳入本研究。其中80.2%（n = 235）为真性分叉病变。单因素分析显示，使用PGW与PMI相关（OR = 4.1；P = 0.002）。在对其他可能的危险因素进行校正后，这种关联仍然显著（OR = 3.5；P = 0.02）。
我们的结果表明，使用PGW进行边支保护可能与PMI有关。需要进行随机研究来验证这些发现。
