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在超级肥胖高患病率队列中,胃旁路术后10年的人体测量参数及合并症的长期缓解情况

Anthropometric parameters and permanent remission of comorbidities 10 years after open gastric bypass in a cohort with high prevalence of super-obesity.

作者信息

Artero Ana, Martinez-Ibañez Juncal, Civera Miguel, Martínez-Valls José Francisco, Ortega-Serrano Joaquín, Real José Tomás, Ascaso Juan Francisco

机构信息

Endocrinology and Nutrition Department, Hospital Clínico Universitario de Valencia, Spain.

Endocrinology and Nutrition Department, Hospital Clínico Universitario de Valencia, Spain.

出版信息

Endocrinol Diabetes Nutr. 2017 Jun-Jul;64(6):310-316. doi: 10.1016/j.endinu.2017.03.013. Epub 2017 May 22.

Abstract

BACKGROUND AND AIM

Roux-en-Y gastric bypass (RYGB) is an effective treatment for weight loss in patients with morbid obesity. However, few studies have assessed its long-term efficacy in super-obese patients. The study objective was to analyse the long-term effectiveness of RYGB and its effect on improvement of comorbidities after 10 years of follow-up, and to compare the results depending on baseline BMI (<50kg/m vs ≥50kg/m).

PATIENTS AND METHODS

A retrospective study was conducted in 63 patients referred for RYGB with a 10-year or longer follow-up period. Mean BMI before surgery was 55kg/m.

RESULTS

Mean BMI decreased to 38.1kg/m at 10 years of follow-up. The success rates according to Reinhold criteria modified by Christou and to Biron's criteria were 30.2% and 54% respectively. The corresponding rates in super-obese patients were 21.4% and 57.1%. Significant, stable improvement was seen in diabetes, dyslipidemia, hypertension, and sleep apnea.

CONCLUSIONS

Sustained weight loss was achieved after gastric bypass, with a mean excess weight loss of 50.6% after 10 years despite the high prevalence of super-obesity. Comorbidity improvement was maintained.

摘要

背景与目的

Roux-en-Y胃旁路术(RYGB)是治疗病态肥胖患者体重减轻的有效方法。然而,很少有研究评估其在超级肥胖患者中的长期疗效。本研究的目的是分析RYGB术后10年的长期疗效及其对合并症改善的影响,并根据基线BMI(<50kg/m²与≥50kg/m²)比较结果。

患者与方法

对63例行RYGB且随访期为10年或更长时间的患者进行了一项回顾性研究。术前平均BMI为55kg/m²。

结果

随访10年时,平均BMI降至38.1kg/m²。根据Christou修改的Reinhold标准和Biron标准的成功率分别为30.2%和54%。超级肥胖患者的相应比率分别为21.4%和57.1%。糖尿病、血脂异常、高血压和睡眠呼吸暂停均有显著且稳定的改善。

结论

胃旁路术后实现了持续的体重减轻,尽管超级肥胖的患病率很高,但10年后平均超重减轻了50.6%。合并症的改善得以维持。

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