姜黄素类似物作为抗氧化剂和抗菌剂的合成与评价
Synthesis and Evaluation of Curcuminoid Analogues as Antioxidant and Antibacterial Agents.
作者信息
Emam Dalia R, Alhajoj Ahmad M, Elattar Khaled M, Kheder Nabila A, Fadda Ahmed A
机构信息
Department of Chemistry, Faculty of Science, King Khalid University, Abha 9004, Saudi Arabia.
Department of Pharmacology, Faculty of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia.
出版信息
Molecules. 2017 Jun 11;22(6):971. doi: 10.3390/molecules22060971.
Diazocoupling reaction of curcumin with different diazonium salts of -toluidine, 2-aminopyridine, and 4-aminoantipyrine in pyridine yielded the arylhydrazones -. Arylhydrazone of -toluidine reacted with urea, thiourea, and guanidine nitrate to produce 5,6-dihydropyrimidines. Further reaction of with 2,3-diaminopyrdine in sodium ethoxide solution yielded 1-pyrido[2,3-][1,4]diazepine derivative. (2,5-dihydroisoxazole) is obtained from the reaction of with hydroxylamine hydrochloride, while its reactions with hydrazines afforded the respective 4,5-dihydro-1-pyrazoles. The target compounds were evaluated as antioxidant and antibacterial agents. The tested compounds showed good to moderate activities compared to ascorbic acid and chloramphenicol, respectively.
姜黄素与对甲苯胺、2-氨基吡啶和4-氨基安替比林的不同重氮盐在吡啶中发生重氮偶合反应，生成芳基腙。对甲苯胺的芳基腙与尿素、硫脲和硝酸胍反应生成5,6-二氢嘧啶。在乙醇钠溶液中，[此处可能缺失前文提及的某个物质]与2,3-二氨基吡啶进一步反应生成1-吡啶并[2,3 - ][1,4]二氮杂卓衍生物。（2,5 - 二氢异恶唑）是由[此处可能缺失前文提及的某个物质]与盐酸羟胺反应得到的，而它与肼反应则生成相应的4,5 - 二氢 - 1 - 吡唑。对目标化合物进行了抗氧化剂和抗菌剂的评估。与抗坏血酸和氯霉素相比，测试的化合物分别显示出良好到中等的活性。
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