文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

使用提取物对Ag/CeO和CuO/CeO纳米复合材料进行环保合成及其抗氧化、抗真菌和细胞毒性活性评估。

Eco-friendly synthesis of Ag/CeO and CuO/CeO nanocomposites using extract and assessment of their antioxidant, antifungal, and cytotoxic activities.

作者信息

Elattar Khaled M, Ghoniem Abeer A, Al-Otibi Fatimah O, Fakhouri Abdulaziz S, Helmy Yosra A, Saber WesamEldin I A, Hassan Mahmoud A E, Elsayed Ashraf

机构信息

Unit of Genetic Engineering and Biotechnology, Faculty of Science, Mansoura University El-Gomhoria St. Mansoura 35516 Egypt

Microbial Activity Unit, Department of Microbiology, Soils, Water and Environment Research Institute, Agricultural Research Center Giza 12619 Egypt

出版信息

RSC Adv. 2025 Apr 17;15(16):12100-12116. doi: 10.1039/d5ra00739a. eCollection 2025 Apr 16.

DOI:10.1039/d5ra00739a
PMID:40248230
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12005080/
Abstract

This work focused on the biosynthesis of Ag/CeO and CuO/CeO nanocomposites (NCs) using extract. The nanocomposites were efficiently characterized using different techniques such as FTIR, UV-visible spectroscopy, zeta potential, DLS, TEM, SEM, EDX, and XRD analyses. The extract provided high phenolic and flavonoid contents, while demonstrating strong antioxidant action at IC = 0.042 mg mL. In particular, both nanocomposites exhibited privileged antifungal activity against with superiority to CuO/CeO (MIC = 29 µg mL) over Ag/CeO (MIC = 49 µg mL). TEM analyses confirmed the adverse effect of nanocomposites on the fungal cell wall. The CuO/CeO structure led to mitochondrial and cytoplasmic damage in MCF-7 cells (IC = 0.5071 µg mL) according to cytotoxicity tests; however, the Ag/CeO NC resulted in significant nuclear damage and an increased occurrence of autophagy events. The nanocomposites showed cytotoxic properties by causing oxidative stress, leading to damage of the genomic material and defects in cell structure, suggesting potential therapeutic applications.

摘要

这项工作聚焦于使用提取物生物合成Ag/CeO和CuO/CeO纳米复合材料（NCs）。采用傅里叶变换红外光谱（FTIR）、紫外可见光谱、zeta电位、动态光散射（DLS）、透射电子显微镜（TEM）、扫描电子显微镜（SEM）、能谱分析（EDX）和X射线衍射（XRD）分析等不同技术对纳米复合材料进行了有效表征。该提取物具有高酚类和黄酮类含量，同时在IC50 = 0.042 mg/mL时表现出强大的抗氧化作用。特别是，两种纳米复合材料均对[具体真菌名称未给出]表现出优异的抗真菌活性，其中CuO/CeO（MIC = 29 µg/mL）优于Ag/CeO（MIC = 49 µg/mL）。TEM分析证实了纳米复合材料对真菌细胞壁的不利影响。根据细胞毒性测试，CuO/CeO结构导致MCF - 7细胞中的线粒体和细胞质损伤（IC50 = 0.5071 µg/mL）；然而，Ag/CeO NC导致显著的核损伤和自噬事件发生率增加。纳米复合材料通过引起氧化应激表现出细胞毒性，导致基因组物质损伤和细胞结构缺陷，表明其具有潜在的治疗应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7353/12005080/9a905fbcf5e0/d5ra00739a-f11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7353/12005080/fd0a85e87a60/d5ra00739a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7353/12005080/eb5e53cd2153/d5ra00739a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7353/12005080/6717a9c0464e/d5ra00739a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7353/12005080/b197b7e9b2fc/d5ra00739a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7353/12005080/9b3694d16fa2/d5ra00739a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7353/12005080/b50c780dfde5/d5ra00739a-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7353/12005080/efe1194dfd1b/d5ra00739a-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7353/12005080/6629462fe126/d5ra00739a-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7353/12005080/61f557db94e1/d5ra00739a-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7353/12005080/1d3fbba55b8b/d5ra00739a-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7353/12005080/9a905fbcf5e0/d5ra00739a-f11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7353/12005080/fd0a85e87a60/d5ra00739a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7353/12005080/eb5e53cd2153/d5ra00739a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7353/12005080/6717a9c0464e/d5ra00739a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7353/12005080/b197b7e9b2fc/d5ra00739a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7353/12005080/9b3694d16fa2/d5ra00739a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7353/12005080/b50c780dfde5/d5ra00739a-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7353/12005080/efe1194dfd1b/d5ra00739a-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7353/12005080/6629462fe126/d5ra00739a-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7353/12005080/61f557db94e1/d5ra00739a-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7353/12005080/1d3fbba55b8b/d5ra00739a-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7353/12005080/9a905fbcf5e0/d5ra00739a-f11.jpg

相似文献

[1]
Eco-friendly synthesis of Ag/CeO and CuO/CeO nanocomposites using extract and assessment of their antioxidant, antifungal, and cytotoxic activities.

RSC Adv. 2025-4-17

[2]
Green synthesis, characterization, and multifunctional applications of Ag@CeO and Ag@CeO-pullulan nanocomposites for dye degradation, antioxidant, and antifungal activities.

Int J Biol Macromol. 2024-11

[3]
Green synthesis of Ag/VO and Ag/VO-curdlan nanocomposites from Sargassum latifolium extract for enhanced antimicrobial and antioxidant activities.

Int J Biol Macromol. 2025-4

[4]
Green synthesis of Ag-ZnO nanocomposites using Trigonella foenum-graecum leaf extract and their antibacterial, antifungal, antioxidant and photocatalytic properties.

Spectrochim Acta A Mol Biomol Spectrosc. 2020-10-15

[5]
Sustainable fabrication of hybrid silver-copper nanocomposites (Ag-CuO NCs) using Ocimum americanum L. as an effective regime against antibacterial, anticancer, photocatalytic dye degradation and microalgae toxicity.

Environ Res. 2023-7-1

[6]
Chemical synthesis, characterization, and anticancer potential of CuO/ZrO/TiO/RGO nanocomposites against human breast (MCF-7) cancer cells.

RSC Adv. 2024-11-25

[7]
Green synthesis of trimetallic CuO/Ag/ZnO nanocomposite using Ziziphus spina-christi plant extract: characterization, statistically experimental designs, and antimicrobial assessment.

Sci Rep. 2024-8-24

[8]
MOF-Mediated Synthesis of CuO/CeO Composite Nanoparticles: Characterization and Estimation of the Cellular Toxicity against Breast Cancer Cell Line (MCF-7).

J Funct Biomater. 2021-9-28

[9]
Enhancing the structural and optoelectronic properties of carboxymethyl cellulose sodium filled with ZnO/GO and CuO/GO nanocomposites for antimicrobial packaging applications.

Sci Rep. 2024-12-23

[10]
Eco-Friendly CuO/FeO Nanocomposite synthesis, characterization, and cytotoxicity study.

Heliyon. 2024-3-8

本文引用的文献

[1]
Green synthesis, characterization, and multifunctional applications of Ag@CeO and Ag@CeO-pullulan nanocomposites for dye degradation, antioxidant, and antifungal activities.

Int J Biol Macromol. 2024-11

[2]
Molecular Engineering for UV-Vis to NIR Absorption/Emission Bands of Pyrazine-based A-π-D- π-A Switches to Design TiO Tuned Dyes: DFT Insights.

J Fluoresc. 2024-9-14

[3]
Synthesis of bimetallic oxides (SrO-CoO) nanoparticles decorated polyacrylamide hydrogels for controlled drug release and wound healing applications.

Int J Biol Macromol. 2024-8

[4]
Optimization of pullulan production by Aureobasidium pullulans using semi-solid-state fermentation and artificial neural networks: Characterization and antibacterial activity of pullulan impregnated with Ag-TiO nanocomposite.

Int J Biol Macromol. 2024-6

[5]
Biosynthesized BiFeO@Ag nanoparticles mediated Scenedesmus obliquus induce apoptosis in AGS gastric cancer cell line.

Sci Rep. 2024-5-4

[6]
Multifaceted chemical and bioactive features of Ag@TiO and Ag@SeO core/shell nanoparticles biosynthesized using L. extract.

Heliyon. 2024-3-22

[7]
Turmeric extract-mediated biogenic synthesis of Ag@SeO magnetic nanoparticles: characterization, optimization, antibacterial and antioxidant activities.

RSC Adv. 2024-2-27

[8]
Cytotoxicity, Antimicrobial, Anti-inflammatory and Antioxidant Activity of Camellia Sinensis and Citrus Mediated Copper Oxide Nanoparticle-An Study.

J Int Soc Prev Community Dent. 2023-12-27

[9]
Biocompatible copper formate-based nanoparticles with strong antibacterial properties for wound healing.

J Nanobiotechnology. 2023-12-10

[10]
Synthesis of novel benzopyrimido[4,5-]azoninone analogs catalyzed by biosynthesized Ag-TiO core/shell magnetic nanocatalyst and assessment of their antioxidant activity.

RSC Adv. 2023-11-6

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索