Cho Sung Hwan, Ahn Eun Hee, An Hui Jeong, Kim Ji Hyang, Ko Jung Jae, Kim Young Ran, Lee Woo Sik, Kim Nam Keun
Department of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, Korea.
Department of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University, Seongnam 13496, Korea.
Int J Mol Sci. 2017 Jun 12;18(6):1255. doi: 10.3390/ijms18061255.
MicroRNAs (miRNAs) post-transcriptionally regulate gene expression in animals and plants. The aim of this study was to investigate whether polymorphisms in are associated with the risk of primary ovarian insufficiency (POI) and POI-related target gene regulation. We identified the G>A polymorphisms within the seed sequence of mature miRNA and aligned the seed sequence with the 3' untranslated region (UTR) of the gonadotropin-releasing hormone receptor () mRNA, a miR-938 target gene. We found that the binding of to the 3'-UTR of mRNA was significantly different between normal and variant alleles. Our data suggests that the dysregulation of G>A influences the binding to and that G>A polymorphisms might contribute to regulation of POI-related target genes.
微小RNA（miRNA）在动植物中通过转录后调控基因表达。本研究的目的是调查[具体基因]中的多态性是否与原发性卵巢功能不全（POI）风险及POI相关靶基因调控有关。我们鉴定了成熟miRNA种子序列内的G>A多态性，并将该种子序列与促性腺激素释放激素受体（[具体基因名称]）mRNA（一种miR-938靶基因）的3'非翻译区（UTR）进行比对。我们发现正常等位基因和变异等位基因之间，[具体基因]与[具体基因名称]mRNA的3'-UTR的结合存在显著差异。我们的数据表明，G>A的失调影响了[具体基因]的结合，并且G>A多态性可能有助于POI相关靶基因的调控。
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