Children's Research Institute, University of Texas Southwestern Medical Center.
Department of Pathology, University of Texas Southwestern Medical Center.
Nat Rev Immunol. 2017 Sep;17(9):573-590. doi: 10.1038/nri.2017.53. Epub 2017 Jun 12.
Stem cell niches are specialized microenvironments that promote the maintenance of stem cells and regulate their function. Recent advances have improved our understanding of the niches that maintain adult haematopoietic stem cells (HSCs). These advances include new markers for HSCs and niche cells, systematic analyses of the expression patterns of niche factors, genetic tools for functionally identifying niche cells in vivo, and improved imaging techniques. Together, they have shown that HSC niches are perivascular in the bone marrow and spleen. Endothelial cells and mesenchymal stromal cells secrete factors that promote HSC maintenance in these niches, but other cell types also directly or indirectly regulate HSC niches.
干细胞龛是促进干细胞维持和调节其功能的专门微环境。最近的进展提高了我们对维持成人造血干细胞 (HSC) 的龛的理解。这些进展包括 HSC 和龛细胞的新标记物、龛因子表达模式的系统分析、体内功能鉴定龛细胞的遗传工具以及改进的成像技术。它们共同表明 HSC 龛在骨髓和脾脏中是血管周围的。内皮细胞和间充质基质细胞分泌促进这些龛中 HSC 维持的因子，但其他细胞类型也直接或间接地调节 HSC 龛。
