Fahmi Selma, Papadogiannakis Nikos, Nasiell Josefine
a Department of Clinical Science , Intervention and Technology, Karolinska Institutet and Karolinska University Hospital , Stockholm , Sweden.
b Department of Laboratory Medicine, Division of Pathology , Section of Perinatal Pathology, Karolinska Institute and Karolinska University Hospital , Stockholm , Sweden.
J Matern Fetal Neonatal Med. 2018 Sep;31(17):2265-2270. doi: 10.1080/14767058.2017.1340447. Epub 2017 Jun 30.
To examine whether different grades of placenta inflammation are associated with risk for spontaneous preterm birth, taking into consideration maternal and delivery factors. Placentas from spontaneous preterm births were compared with a control group from full-term deliveries.
Placentas from 98 full-term, 71 late preterm (gestational week 34-37), and 65 early preterm (gestational week 22-33) singleton deliveries were analysed from the Karolinska University Hospital in Stockholm. The placentas were examined for histologic chorioamnionitis (HCA) grade 1 (low) and 2 (high). Mother, child, and delivery parameters were collected from maternity centre and delivery forms.
There was a relatively low incidence of HCA in the preterm groups (26.7% and 38.5% in the late and early preterm groups, respectively). HCA 2 was most common in the early preterm group and HCA 1 was most common in the full-term group. The odds of early preterm birth was lower for placentas with HCA 1 compared to HCA 2 (OR = 0.17) and higher for placentas with HCA 2 compared to no HCA (OR = 2.17).
Despite a relatively low incidence of HCA in the preterm groups, HCA 2 seems to be associated with early preterm birth whereas HCA 1 seems to be part of the full-term delivery.
考虑到母亲和分娩因素，研究不同等级的胎盘炎症是否与自发性早产风险相关。将自发性早产的胎盘与足月分娩的对照组胎盘进行比较。
对斯德哥尔摩卡罗林斯卡大学医院的98例足月、71例晚期早产（孕34 - 37周）和65例早期早产（孕22 - 33周）单胎分娩的胎盘进行分析。检查胎盘的组织学绒毛膜羊膜炎（HCA）1级（低）和2级（高）。从产科中心和分娩表格中收集母亲、孩子和分娩参数。
早产组中HCA的发生率相对较低（晚期早产组和早期早产组分别为26.7%和38.5%）。HCA 2在早期早产组中最常见，HCA 1在足月组中最常见。与HCA 2相比，HCA 1的胎盘发生早期早产的几率较低（OR = 0.17），与无HCA相比，HCA 2的胎盘发生早期早产的几率较高（OR = 2.17）。
尽管早产组中HCA的发生率相对较低，但HCA 2似乎与早期早产相关，而HCA 1似乎是足月分娩的一部分。
