全反式维甲酸对足细胞损伤保护作用的研究进展
[Research advances in the protective effect of all-trans retinoic acid against podocyte injury].
作者信息
Chen Xiu-Ping, Qin Yuan-Han
机构信息
Department of Pediatrics, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
出版信息
Zhongguo Dang Dai Er Ke Za Zhi. 2017 Jun;19(6):719-723. doi: 10.7499/j.issn.1008-8830.2017.06.020.
Abstract
All-trans retinoic acid (ATRA) is a vitamin A derivative and plays an important role in the regulation of cell aggregation, differentiation, apoptosis, proliferation, and inflammatory response. In recent years, some progress has been made in the role of ATRA in renal diseases, especially its protective effect on podocytes. This article reviews the research advances in podocyte injury, characteristics of ATRA, podocyte differentiation and regeneration induced by ATRA, and the protective effect of ATRA against proliferation, deposition of fibers, and apoptosis.
摘要
全反式维甲酸（ATRA）是一种维生素A衍生物，在细胞聚集、分化、凋亡、增殖及炎症反应的调节中发挥重要作用。近年来，ATRA在肾脏疾病中的作用取得了一些进展，尤其是其对足细胞的保护作用。本文综述了足细胞损伤、ATRA的特性、ATRA诱导的足细胞分化与再生，以及ATRA对增殖、纤维沉积和凋亡的保护作用等方面的研究进展。
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