Weston Dale, Blackburn Ruth, Potts Henry W W, Hayward Andrew C
Behavioural Science Team, Emergency Response Department Science & Technology, Public Health England, Porton Down, Salisbury, UK.
Institute of Health Informatics & Institute of Epidemiology and Healthcare, University College London, UK.
Vaccine. 2017 Jul 5;35(31):3875-3882. doi: 10.1016/j.vaccine.2017.05.061. Epub 2017 Jun 9.
During the 2009 H1N1 pandemic, UK uptake of the pandemic influenza vaccine was very low. Furthermore, attitudes governing UK vaccination uptake during a pandemic are poorly characterised. To the best of our knowledge, there is no published research explicitly considering predictors of both adult self-vaccination and decisions regarding whether or not to vaccinate one's children among the UK population during the H1N1 pandemic. We therefore aimed to identify predictors of both self-vaccination decisions and parental vaccination decisions using data collected during the H1N1 pandemic as part of the Flu Watch cohort study. Data were analysed separately for 798 adults and 85 children: exploratory factor analysis facilitated reduction of 16 items on attitudes to pandemic vaccine into a smaller number of factors. Single variable analyses with vaccine uptake as the outcome were used to identify variables that were predictive of vaccination in children and adults. Potential predictors were: attitudinal factors created by data reduction, age group, sex, region, deprivation, ethnicity, chronic condition, vocation, healthcare-related occupation and previous influenza vaccination. Consistent with previous literature concerning adult self-vaccination decisions, we found that vaccine efficacy/safety and perceived risk of pandemic influenza were significant predictors of both self-vaccination decisions and parental vaccination decisions. This study provides the first systematic attempt to understand both the predictors of self and parental vaccination uptake among the UK general population during the H1N1 pandemic. Our findings indicate that concerns about vaccine safety, and vaccine effectiveness may be a barrier to increased uptake for both self and parental vaccination.
在2009年甲型H1N1流感大流行期间,英国大流行性流感疫苗的接种率非常低。此外,关于英国在大流行期间疫苗接种情况的态度特征尚不明确。据我们所知,尚无已发表的研究明确考虑在甲型H1N1流感大流行期间英国人群中成人自我接种疫苗以及是否为子女接种疫苗的决定的预测因素。因此,我们旨在利用作为流感观察队列研究一部分在甲型H1N1流感大流行期间收集的数据,确定自我接种疫苗决定和父母接种疫苗决定的预测因素。对798名成年人和85名儿童的数据进行了单独分析:探索性因素分析有助于将关于大流行疫苗态度的16个项目减少为较少数量的因素。以疫苗接种率为结果的单变量分析用于确定儿童和成人中预测接种疫苗的变量。潜在的预测因素包括:数据简化产生的态度因素、年龄组、性别、地区、贫困程度、种族、慢性病、职业、医疗保健相关职业以及以前的流感疫苗接种情况。与先前关于成人自我接种疫苗决定的文献一致,我们发现疫苗效力/安全性和感知的甲型H1N1流感风险是自我接种疫苗决定和父母接种疫苗决定的重要预测因素。本研究首次系统地尝试了解在甲型H1N1流感大流行期间英国普通人群中自我接种疫苗和父母接种疫苗的预测因素。我们的研究结果表明,对疫苗安全性和有效性的担忧可能是自我接种疫苗和父母接种疫苗接种率提高的障碍。