Murdaca Giuseppe, Noberasco Giovanni, Olobardi Dario, Lunardi Claudio, Maule Matteo, Delfino Lorenzo, Triggiani Massimo, Cardamone Chiara, Benfaremo Devis, Moroncini Gianluca, Vacca Angelo, Susca Nicola, Gangemi Sebastiano, Quattrocchi Paola, Sticchi Laura, Icardi Giancarlo, Orsi Andrea
Departments of Internal Medicine, University of Genova, 16132 Genova, Italy.
Department of Health Sciences, University of Genova, 16132 Genova, Italy.
Vaccines (Basel). 2021 Dec 2;9(12):1426. doi: 10.3390/vaccines9121426.
Systemic sclerosis (SSc) is a rare autoimmune inflammatory rheumatic disease. The prevalence of SSc ranges from 7 to 700 cases per million worldwide. Due to multiple organ involvement and constant inflammatory state, this group of patients presents an increased risk of infectious diseases. This paper aimed to gather the up-to-date evidence on vaccination strategies for patients with SSc and to be a useful tool for the prevention and management of infectious diseases. The authors conducted a scoping review in which each paragraph presents data on a specific vaccine's safety, immunogenicity, and efficacy. The work deals with the following topics: SARS-CoV-2, seasonal influenza, , HAV, HBV, HZV, , , HPV, and diphtheria-tetanus-pertussis.
系统性硬化症（SSc）是一种罕见的自身免疫性炎性风湿性疾病。全球范围内，SSc的患病率为每百万人7至700例。由于多器官受累以及持续的炎症状态，这类患者发生感染性疾病的风险增加。本文旨在收集关于SSc患者疫苗接种策略的最新证据，并成为预防和管理感染性疾病的有用工具。作者进行了一项范围综述，其中每一段都呈现了关于特定疫苗的安全性、免疫原性和有效性的数据。该研究涉及以下主题：严重急性呼吸综合征冠状病毒2（SARS-CoV-2）、季节性流感、甲型肝炎病毒（HAV）、乙型肝炎病毒（HBV）、带状疱疹病毒（HZV）、人乳头瘤病毒（HPV）以及白喉-破伤风-百日咳疫苗。
