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Targeting Cadherin-11 Prevents Notch1-Mediated Calcific Aortic Valve Disease.

作者信息

Clark Cynthia R, Bowler Meghan A, Snider J Caleb, Merryman W David

机构信息

From Department of Biomedical Engineering, Vanderbilt University, Nashville, TN.

出版信息

Circulation. 2017 Jun 13;135(24):2448-2450. doi: 10.1161/CIRCULATIONAHA.117.027771.

DOI:10.1161/CIRCULATIONAHA.117.027771
PMID:28606953
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5523848/
Abstract
摘要

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本文引用的文献

1
Altered DNA Methylation of Long Noncoding RNA H19 in Calcific Aortic Valve Disease Promotes Mineralization by Silencing NOTCH1.长链非编码 RNA H19 的 DNA 甲基化改变通过沉默 NOTCH1 促进钙化性主动脉瓣疾病的矿化。
Circulation. 2016 Dec 6;134(23):1848-1862. doi: 10.1161/CIRCULATIONAHA.116.023116. Epub 2016 Oct 27.
2
Lnc-ing NOTCH1 to Idiopathic Calcific Aortic Valve Disease.长链非编码RNA-ING NOTCH1与特发性钙化性主动脉瓣疾病
Circulation. 2016 Dec 6;134(23):1863-1865. doi: 10.1161/CIRCULATIONAHA.116.025601. Epub 2016 Oct 27.
3
Notch1 Mutation Leads to Valvular Calcification Through Enhanced Myofibroblast Mechanotransduction.
解开瓣膜性心脏病的机制，以确定医学治疗靶点：美国心脏协会的科学声明。
Circulation. 2024 Aug 6;150(6):e109-e128. doi: 10.1161/CIR.0000000000001254. Epub 2024 Jun 17.
4
Cdh11: Roles in different diseases and potential value in disease diagnosis and treatment.Cdh11：在不同疾病中的作用以及在疾病诊断和治疗中的潜在价值。
Biochem Biophys Rep. 2023 Nov 15;36:101576. doi: 10.1016/j.bbrep.2023.101576. eCollection 2023 Dec.
5
Calcific aortic valve disease: mechanisms, prevention and treatment.钙化性主动脉瓣疾病：机制、预防和治疗。
Nat Rev Cardiol. 2023 Aug;20(8):546-559. doi: 10.1038/s41569-023-00845-7. Epub 2023 Feb 24.
6
Sclerostin ablation prevents aortic valve stenosis in mice.骨硬化蛋白消融可预防小鼠主动脉瓣狭窄。
Am J Physiol Heart Circ Physiol. 2022 Nov 1;323(5):H1037-H1047. doi: 10.1152/ajpheart.00355.2022. Epub 2022 Oct 14.
7
Evaluation of early bilateral ovariectomy in mice as a model of left heart disease.评价双侧卵巢切除术在小鼠模型中的应用，用于研究左心疾病。
Am J Physiol Heart Circ Physiol. 2022 Jun 1;322(6):H1080-H1085. doi: 10.1152/ajpheart.00157.2022. Epub 2022 Apr 29.
8
Rac1 mediates cadherin-11 induced cellular pathogenic processes in aortic valve calcification.Rac1 介导钙黏蛋白 11 诱导的主动脉瓣钙化中的细胞致病过程。
Cardiovasc Pathol. 2022 May-Jun;58:107414. doi: 10.1016/j.carpath.2022.107414. Epub 2022 Jan 21.
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4
Cadherin-11 regulates cell-cell tension necessary for calcific nodule formation by valvular myofibroblasts.钙黏蛋白 11 通过瓣膜成纤维细胞调节细胞间张力，这对于钙化结节的形成是必要的。
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