Targeting Cadherin-11 Prevents Notch1-Mediated Calcific Aortic Valve Disease.
作者信息
Clark Cynthia R, Bowler Meghan A, Snider J Caleb, Merryman W David
机构信息
From Department of Biomedical Engineering, Vanderbilt University, Nashville, TN.
出版信息
Circulation. 2017 Jun 13;135(24):2448-2450. doi: 10.1161/CIRCULATIONAHA.117.027771.
Abstract
摘要
相似文献
1
Targeting Cadherin-11 Prevents Notch1-Mediated Calcific Aortic Valve Disease.靶向钙黏蛋白-11可预防Notch1介导的钙化性主动脉瓣疾病。
Circulation. 2017 Jun 13;135(24):2448-2450. doi: 10.1161/CIRCULATIONAHA.117.027771.
2
Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease.内皮型一氧化氮信号通路调控主动脉瓣疾病中的 Notch1。
J Mol Cell Cardiol. 2013 Jul;60:27-35. doi: 10.1016/j.yjmcc.2013.04.001. Epub 2013 Apr 11.
3
Aortic calcified particles modulate valvular endothelial and interstitial cells.主动脉钙化颗粒调节瓣膜内皮细胞和间质细胞。
Cardiovasc Pathol. 2017 May-Jun;28:36-45. doi: 10.1016/j.carpath.2017.02.006. Epub 2017 Mar 3.
4
MicroRNA Expression Signature in Human Calcific Aortic Valve Disease.人类钙化性主动脉瓣疾病中的微小RNA表达特征
Biomed Res Int. 2017;2017:4820275. doi: 10.1155/2017/4820275. Epub 2017 Apr 11.
5
The LDLR deficient mouse as a model for aortic calcification and quantification by micro-computed tomography.LDLR 缺陷型小鼠作为主动脉钙化模型及其通过微计算机断层扫描定量分析。
Atherosclerosis. 2011 Dec;219(2):455-62. doi: 10.1016/j.atherosclerosis.2011.08.035. Epub 2011 Aug 26.
6
Notch1 Mutation Leads to Valvular Calcification Through Enhanced Myofibroblast Mechanotransduction.Notch1突变通过增强肌成纤维细胞机械转导导致瓣膜钙化。
Arterioscler Thromb Vasc Biol. 2015 Jul;35(7):1597-605. doi: 10.1161/ATVBAHA.114.305095. Epub 2015 May 28.
7
Genetic basis of familial valvular heart disease.家族性心脏瓣膜病的遗传基础。
Circ Cardiovasc Genet. 2012 Oct 1;5(5):569-80. doi: 10.1161/CIRCGENETICS.112.962894.
8
Vitamin K2 can suppress the expression of Toll-like receptor 2 (TLR2) and TLR4, and inhibit calcification of aortic intima in ApoE mice as well as smooth muscle cells.维生素K2可抑制Toll样受体2（TLR2）和TLR4的表达，并抑制载脂蛋白E（ApoE）小鼠主动脉内膜以及平滑肌细胞的钙化。
Vascular. 2018 Feb;26(1):18-26. doi: 10.1177/1708538117713395. Epub 2017 Jun 6.
9
Msx2 is required for vascular smooth muscle cells osteoblastic differentiation but not calcification in insulin-resistant ob/ob mice.Msx2 对于胰岛素抵抗 ob/ob 小鼠血管平滑肌细胞成骨样分化而非钙化是必需的。
Atherosclerosis. 2017 Oct;265:14-21. doi: 10.1016/j.atherosclerosis.2017.07.028. Epub 2017 Jul 29.
10
Inhibition of FOXO1/3 promotes vascular calcification.抑制FOXO1/3会促进血管钙化。
Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):175-83. doi: 10.1161/ATVBAHA.114.304786. Epub 2014 Nov 6.
引用本文的文献
1
Galectin-3-integrin α5β1 phase separation disrupted by advanced glycation end-products impairs diabetic wound healing in rodents.晚期糖基化终产物破坏半乳糖凝集素-3-整合素α5β1相分离，损害啮齿动物的糖尿病伤口愈合。
Nat Commun. 2025 Aug 7;16(1):7287. doi: 10.1038/s41467-025-62320-w.
2
Unraveling the Enigma of Moderate Aortic Stenosis: Challenges and Future Prospects.揭开中度主动脉瓣狭窄之谜：挑战与未来前景
J Clin Med. 2024 Jun 14;13(12):3478. doi: 10.3390/jcm13123478.
3
Unraveling the Mechanisms of Valvular Heart Disease to Identify Medical Therapy Targets: A Scientific Statement From the American Heart Association.解开瓣膜性心脏病的机制，以确定医学治疗靶点：美国心脏协会的科学声明。
Circulation. 2024 Aug 6;150(6):e109-e128. doi: 10.1161/CIR.0000000000001254. Epub 2024 Jun 17.
4
Cdh11: Roles in different diseases and potential value in disease diagnosis and treatment.Cdh11：在不同疾病中的作用以及在疾病诊断和治疗中的潜在价值。
Biochem Biophys Rep. 2023 Nov 15;36:101576. doi: 10.1016/j.bbrep.2023.101576. eCollection 2023 Dec.
5
Calcific aortic valve disease: mechanisms, prevention and treatment.钙化性主动脉瓣疾病：机制、预防和治疗。
Nat Rev Cardiol. 2023 Aug;20(8):546-559. doi: 10.1038/s41569-023-00845-7. Epub 2023 Feb 24.
6
Sclerostin ablation prevents aortic valve stenosis in mice.骨硬化蛋白消融可预防小鼠主动脉瓣狭窄。
Am J Physiol Heart Circ Physiol. 2022 Nov 1;323(5):H1037-H1047. doi: 10.1152/ajpheart.00355.2022. Epub 2022 Oct 14.
7
Evaluation of early bilateral ovariectomy in mice as a model of left heart disease.评价双侧卵巢切除术在小鼠模型中的应用，用于研究左心疾病。
Am J Physiol Heart Circ Physiol. 2022 Jun 1;322(6):H1080-H1085. doi: 10.1152/ajpheart.00157.2022. Epub 2022 Apr 29.
8
Rac1 mediates cadherin-11 induced cellular pathogenic processes in aortic valve calcification.Rac1 介导钙黏蛋白 11 诱导的主动脉瓣钙化中的细胞致病过程。
Cardiovasc Pathol. 2022 May-Jun;58:107414. doi: 10.1016/j.carpath.2022.107414. Epub 2022 Jan 21.
9
Evaluating Medical Therapy for Calcific Aortic Stenosis: JACC State-of-the-Art Review.评估钙化性主动脉瓣狭窄的医学治疗：JACC 最新综述。
J Am Coll Cardiol. 2021 Dec 7;78(23):2354-2376. doi: 10.1016/j.jacc.2021.09.1367.
10
Fibroblast pathology in inflammatory diseases.炎症性疾病中的成纤维细胞病理学。
J Clin Invest. 2021 Oct 15;131(20). doi: 10.1172/JCI149538.
本文引用的文献
1
Altered DNA Methylation of Long Noncoding RNA H19 in Calcific Aortic Valve Disease Promotes Mineralization by Silencing NOTCH1.长链非编码 RNA H19 的 DNA 甲基化改变通过沉默 NOTCH1 促进钙化性主动脉瓣疾病的矿化。
Circulation. 2016 Dec 6;134(23):1848-1862. doi: 10.1161/CIRCULATIONAHA.116.023116. Epub 2016 Oct 27.
2
Lnc-ing NOTCH1 to Idiopathic Calcific Aortic Valve Disease.长链非编码RNA-ING NOTCH1与特发性钙化性主动脉瓣疾病
Circulation. 2016 Dec 6;134(23):1863-1865. doi: 10.1161/CIRCULATIONAHA.116.025601. Epub 2016 Oct 27.
3
Notch1 Mutation Leads to Valvular Calcification Through Enhanced Myofibroblast Mechanotransduction.Notch1突变通过增强肌成纤维细胞机械转导导致瓣膜钙化。
Arterioscler Thromb Vasc Biol. 2015 Jul;35(7):1597-605. doi: 10.1161/ATVBAHA.114.305095. Epub 2015 May 28.
4
Cadherin-11 regulates cell-cell tension necessary for calcific nodule formation by valvular myofibroblasts.钙黏蛋白 11 通过瓣膜成纤维细胞调节细胞间张力，这对于钙化结节的形成是必要的。
Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):114-20. doi: 10.1161/ATVBAHA.112.300278. Epub 2012 Nov 15.
5
Mutations in NOTCH1 cause aortic valve disease.NOTCH1基因的突变会导致主动脉瓣疾病。
Nature. 2005 Sep 8;437(7056):270-4. doi: 10.1038/nature03940. Epub 2005 Jul 17.
Zotero 插件