Fomenko A I, Khalmuradov A G, Khustochka L N, Pozharum S V, Stepanenko S P
Ukr Biokhim Zh (1978). 1985 Mar-Apr;57(2):31-6.
Nicotinic acid in vivo affects the citrate demand for acetyl-CoA-carboxylase activation in the chicken liver under conditions of alimentary lipogenesis stimulation. Stoichiometry of the citrate binding with the dissociation constant of the enzyme-allosteric activator complex is determined under experimental conditions. Endogenic phosphorylation of acetyl-CoA-carboxylase completely correlates with its inactivation and depends on the citrate level. cAMP is established to have an activating effect on phosphorylation of acetyl-CoA-carboxylase of test animals.
在营养性脂肪生成刺激条件下，体内烟酸会影响鸡肝脏中柠檬酸对乙酰辅酶A羧化酶激活的需求。在实验条件下测定了柠檬酸与酶变构激活剂复合物解离常数结合的化学计量关系。乙酰辅酶A羧化酶的内源性磷酸化与其失活完全相关，并取决于柠檬酸水平。已证实cAMP对实验动物的乙酰辅酶A羧化酶磷酸化具有激活作用。
