碳水化合物限制与脂肪限制对2型糖尿病合并冠心病超重患者代谢谱、炎症生物标志物和氧化应激的比较影响：一项随机临床试验。
Comparative effects of carbohydrate versus fat restriction on metabolic profiles, biomarkers of inflammation and oxidative stress in overweight patients with Type 2 diabetic and coronary heart disease: A randomized clinical trial.
作者信息
Raygan Fariba, Bahmani Fereshteh, Kouchaki Ebrahim, Aghadavod Esmat, Sharifi Sahar, Akbari Elmira, Heidari Akbar, Asemi Zatollah
机构信息
Department of Cardiology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
出版信息
ARYA Atheroscler. 2016 Nov;12(6):266-273.
BACKGROUND
This study was conducted to establish the comparative effects of carbohydrate versus fat restriction on metabolic indices in Type 2 diabetic (T2D) patients with coronary heart disease (CHD).
METHODS
This randomized, clinical trial was done among 56 overweight persons with T2D and CHD aged 40-85 years old. The patients were randomly allocated to take either a high-carbohydrate (HC) diet (60-65% carbohydrates and 20-25% fats) (n = 28) or a restricted carbohydrate (RC) diet (43-49% carbohydrate and 36-40% fats) (n = 28) for 8 weeks to determine metabolic status.
RESULTS
After 8 weeks of treatment, RC diet decreased fasting plasma glucose (FPG) (-11.5 ± 28.3 vs. +7.0 ± 26.9 mg/dl, P = 0.010) and high-sensitivity C-reactive protein (hs-CRP) (-564.3 ± 1280.1 vs. +286.1 ± 1789.2 ng/ml, P = 0.040) compared with a HC diet. Moreover, compared with a HC diet, RC diet increased total antioxidant capacity (TAC) (+274.8 ± 111.5 vs. +20.2 ± 82.5 mmol/l, P < 0.001) and glutathione (GSH) levels (+51.6 ± 111.5 vs. -32.6 ± 88.5 µmol/l, P = 0.003). No significant alterations between the two groups were found in terms of their effect on other metabolic profiles.
CONCLUSION
RC diet in overweight T2D with CHD had beneficial effects on FPG, hs-CRP, TAC, and GSH values.
背景
本研究旨在确定碳水化合物限制饮食与脂肪限制饮食对2型糖尿病（T2D）合并冠心病（CHD）患者代谢指标的比较效果。
方法
本随机临床试验纳入了56名年龄在40 - 85岁之间的超重T2D合并CHD患者。患者被随机分配接受高碳水化合物（HC）饮食（碳水化合物含量60 - 65%，脂肪含量20 - 25%）（n = 28）或碳水化合物限制（RC）饮食（碳水化合物含量43 - 49%，脂肪含量36 - 40%）（n = 28），为期8周，以确定代谢状况。
结果
治疗8周后，与HC饮食相比，RC饮食降低了空腹血糖（FPG）（-11.5 ± 28.3 vs. +7.0 ± 26.9 mg/dl，P = 0.010）和高敏C反应蛋白（hs-CRP）（-564.3 ± 1280.1 vs. +286.1 ± 1789.2 ng/ml，P = 0.040）。此外，与HC饮食相比，RC饮食提高了总抗氧化能力（TAC）（+274.8 ± 111.5 vs. +20.2 ± 82.5 mmol/l，P < 0.001）和谷胱甘肽（GSH）水平（+51.6 ± 111.5 vs. -32.6 ± 88.5 µmol/l，P = 0.003）。两组在对其他代谢指标的影响方面未发现显著差异。
结论
超重T2D合并CHD患者采用RC饮食对FPG、hs-CRP、TAC和GSH值有有益影响。
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