病毒感染的B细胞在狨猴实验性自身免疫性脑脊髓炎模型中的重要作用。
An essential role of virus-infected B cells in the marmoset experimental autoimmune encephalomyelitis model.
作者信息
't Hart Bert A, Kap Yolanda S
机构信息
Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands.
出版信息
Mult Scler J Exp Transl Clin. 2017 Jan 1;3(1):2055217317690184. doi: 10.1177/2055217317690184. eCollection 2017 Jan-Mar.
Infection with Epstein-Barr virus (EBV) has been associated with an enhanced risk of genetically susceptible individuals to develop multiple sclerosis (MS). However, an explanation for the contrast between the high EBV infection prevalence (60-90%) and the low MS prevalence (0.1%) eludes us. Here we propose a new concept for the EBV-MS association developed in the experimental autoimmune encephalomyelitis model in marmoset monkeys, which are naturally infected with the EBV-related γ1-herpesvirus CalHV3. The data indicate that the infection of B cells with a γ1-herpesvirus endows them with the capacity to activate auto-aggressive CD8+ T cells specific for myelin oligodendrocyte glycoprotein.
感染爱泼斯坦-巴尔病毒（EBV）与遗传易感性个体患多发性硬化症（MS）的风险增加有关。然而，我们仍无法解释EBV高感染率（60-90%）与MS低患病率（0.1%）之间的差异。在此，我们基于在自然感染EBV相关γ1-疱疹病毒CalHV3的狨猴实验性自身免疫性脑脊髓炎模型中得出的结果，提出了一个关于EBV与MS关联的新概念。数据表明，γ1-疱疹病毒感染B细胞使其具备激活针对髓鞘少突胶质细胞糖蛋白的自身攻击性CD8 + T细胞的能力。
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