McCoy G D, Lobel P, DeMarco G J
Alcohol Clin Exp Res. 1985 Mar-Apr;9(2):131-2. doi: 10.1111/j.1530-0277.1985.tb05534.x.
The effect of 28-day ethanol consumption on hamster liver microsomal electron transport systems and associated enzymatic activities has been examined. Microsomes isolated from ethanol-consuming hamsters showed increased levels of cytochrome P-450 and NADPH supported enzymatic activities. In contrast, reductions in the amount of cytochrome b5 and the NADH-supported rate of stearoyl-CoA desaturase were observed. NADH-cytochrome c reductase was decreased while a small increase in NADH-ferricyanide reductase was observed. These data suggest that decreased stearoyl-CoA desaturase activity is the result of lowered cytochrome b5 levels in microsomes isolated from ethanol-consuming hamsters.
研究了28天乙醇摄入对仓鼠肝微粒体电子传递系统及相关酶活性的影响。从摄入乙醇的仓鼠中分离出的微粒体显示细胞色素P-450水平升高以及NADPH支持的酶活性增加。相反，观察到细胞色素b5的量减少以及硬脂酰辅酶A去饱和酶的NADH支持率降低。NADH-细胞色素c还原酶减少，而NADH-铁氰化物还原酶略有增加。这些数据表明，硬脂酰辅酶A去饱和酶活性降低是从摄入乙醇的仓鼠中分离出的微粒体中细胞色素b5水平降低的结果。
