Binnenmars S Heleen, Hijmans R S, Navis G, de Borst M H
University of Groningen, University Medical Center Groningen, Department of Internal Medicine, Division of Nephrology, Groningen, The Netherlands.
Clin Pharmacol Ther. 2017 Sep;102(3):481-492. doi: 10.1002/cpt.765. Epub 2017 Jul 21.
This review provides an overview of the clinical value of the most relevant renal biomarkers, focusing on two main clinical conditions: acute kidney injury and chronic kidney disease. We categorize biomarkers according to their actionability, in terms of a documented response to treatment in relation to outcomes. Furthermore, we introduce a new category of renal biomarkers, metabolic biomarkers, and underscore their capacity to be highly actionable.
本综述概述了最相关的肾脏生物标志物的临床价值,重点关注两种主要临床情况:急性肾损伤和慢性肾脏病。我们根据生物标志物的可操作性对其进行分类,即根据与治疗结果相关的已记录的治疗反应。此外,我们引入了一类新的肾脏生物标志物——代谢生物标志物,并强调了它们具有高度可操作性的能力。