Gungor Ozkan, Kocyigit Ismail, Yilmaz Mahmut Ilker, Sezer Siren
Department of Nephrology, Faculty of Medicine, Kahramanmaraş Sütçü İmam University, Kahramanmaras, Turkey.
Department of Nephrology, Erciyes University Faculty of Medicine, Kayseri, Turkey.
Semin Dial. 2018 Jan;31(1):72-81. doi: 10.1111/sdi.12616. Epub 2017 Jun 13.
Cardiovascular events make up the primary cause of death in hemodialysis patients, and the risk for cardiovascular mortality is significantly increased by vascular calcification, a condition observed frequently in this patient population. The mechanisms underlying the pathogenesis of vascular calcification are complex, and many factors facilitate or hinder the development of calcification. In this review, we first summarize the main factors contributing to the pathogenesis of vascular calcification in patients with end-stage renal disease. We then explore the role of calcification inhibitors in the calcification process, as well as their effect on vascular dysfunction and mortality in hemodialysis patients.
心血管事件是血液透析患者的主要死因，而血管钙化会显著增加心血管死亡风险，这种情况在该患者群体中经常出现。血管钙化发病机制背后的机制很复杂，许多因素促进或阻碍钙化的发展。在本综述中，我们首先总结导致终末期肾病患者血管钙化发病机制的主要因素。然后，我们探讨钙化抑制剂在钙化过程中的作用，以及它们对血液透析患者血管功能障碍和死亡率的影响。
