仓鼠和大鼠中牛磺酸与维拉帕米相互作用的比较。

Comparison of taurine-verapamil interaction in hamsters and rats.

作者信息

McBroom M J, Welty J D

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1985;80(2):217-9. doi: 10.1016/0742-8413(85)90045-3.

Abstract

Taurine concentrations were determined in hearts and whole blood of female Syrian golden hamsters and Wistar rats following 30 days of drinking: (i) tap water, (ii) taurine solution or (iii) a taurine uptake inhibitor (GES). The groups were duplicated in animals receiving daily verapamil injections during the treatment period. Heart taurine increased with (ii) and decreased with (iii) in both species; blood taurine changed similarly in rats only. Verapamil enhanced taurine uptake and offset the GES inhibition in the hamster heart, but had no such effect in rats. Possible implications of the species differences are elaborated upon.

摘要

在雌性叙利亚金黄地鼠和Wistar大鼠饮用30天以下液体后，测定其心脏和全血中的牛磺酸浓度：(i) 自来水；(ii) 牛磺酸溶液；或(iii) 一种牛磺酸摄取抑制剂（GES）。在治疗期间，对每日接受维拉帕米注射的动物进行分组复制。在这两个物种中，心脏牛磺酸含量在(ii)组增加，在(iii)组减少；仅在大鼠中，血液牛磺酸变化情况类似。维拉帕米增强了地鼠心脏对牛磺酸的摄取，并抵消了GES的抑制作用，但对大鼠没有这种作用。文中阐述了物种差异可能产生的影响。