海鞘Halocynthia aurantium的肌肉化学感受器。

The muscle chemoreceptors of the ascidian Halocynthia aurantium.

作者信息

Kobzar G T, Shelkovnikov S A

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1985;80(2):395-400. doi: 10.1016/0742-8413(85)90074-x.

Abstract

The body wall muscle of the ascidian, Halocynthia aurantium, is sensitive to both nicotinomimetics and muscarinomimetics. Atropine (4 X 10(-11 M) and benzilylcholine mustard (1 X 10(-5) M for 15 min) selectively block responses to muscarinomimetics. d-Tubocurarine (2 X 10(-6) M) and hexadecamethylene-bis-trimethylammonium (2 X 10(-7) M) prevent contractions induced by both nicotinomimetics and muscarinomimetics. In the cold season of the year the sensitivity of the muscle to muscarinomimetics disappears while responses to nicotinomimetics do not change throughout the year. The cooling of the water in the experimental bath results in an increase in the muscle contractions caused by muscarinomimetics while the responses to nicotinomimetic propionylcholine do not change. Catecholamines induce a decrease of the ascidian muscle responses to acetylcholine, cGMP and papaverine produce a similar effect.

摘要

海鞘Halocynthia aurantium的体壁肌肉对烟碱样拟似剂和毒蕈碱样拟似剂均敏感。阿托品（4×10⁻¹¹ M）和苯甲酰胆碱氮芥（1×10⁻⁵ M，作用15分钟）选择性阻断对毒蕈碱样拟似剂的反应。d -筒箭毒碱（2×10⁻⁶ M）和十六亚甲基双三甲铵（2×10⁻⁷ M）可阻止烟碱样拟似剂和毒蕈碱样拟似剂诱导的收缩。在一年中的寒冷季节，肌肉对毒蕈碱样拟似剂的敏感性消失，而对烟碱样拟似剂的反应全年不变。实验浴中水温降低会导致毒蕈碱样拟似剂引起的肌肉收缩增加，而对烟碱样拟似剂丙酰胆碱的反应不变。儿茶酚胺会使海鞘肌肉对乙酰胆碱的反应减弱，环磷酸鸟苷（cGMP）和罂粟碱也产生类似作用。