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Inhibition of stimulated osmotic water flow by fluphenazine, a calmodulin inhibitor, in the isolated toad skin.

作者信息

Berman D M

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1985;81(1):203-8. doi: 10.1016/0742-8413(85)90115-x.

DOI:10.1016/0742-8413(85)90115-x
PMID:2861050
Abstract

The effects of fluphenazine, a phenothiazine calmodulin inhibitor, on the osmotic water flow (Posm) across isolated skins of Bufo arenarum toads were tested. Fluphenazine inhibited the increase in Posm induced by agents known to act through the cyclic AMP system (oxytocin, db-cAMP, theophylline, KCl and isoproterenol). The inhibitory effect was faster and more intense when the drug was present in the epidermal bath, and persisted after rinsing the preparation for 100 min. Our results indicate that phenothiazine's action may be primarily exerted at a site distal to cyclic AMP generation.

摘要

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引用本文的文献

1
Phenothiazines increase active sodium transport across the isolated toad skin.吩噻嗪可增加钠在离体蟾蜍皮肤中的主动转运。
Pflugers Arch. 1986 Sep;407(3):327-32. doi: 10.1007/BF00585310.