Joumard-Cubizolles Laurie, Lee Jetty Chung-Yung, Vigor Claire, Leung Ho Hang, Bertrand-Michel Justine, Galano Jean-Marie, Mazur André, Durand Thierry, Gladine Cecile
INRA, Université Clermont Auvergne, UNH, Unité de Nutrition Humaine, CRNH Auvergne, F-63000 Clermont-Ferrand, France.
School of Biological Sciences, The University of Hong Kong, Hong Kong.
Prostaglandins Other Lipid Mediat. 2017 Nov;133:111-122. doi: 10.1016/j.prostaglandins.2017.05.005. Epub 2017 Jun 10.
Omega 3 polyunsaturated fatty acids have been reported to confer beneficial health effects notably in the field of cardiovascular and inflammatory diseases. The current knowledge suggests a significant portion of the effects of omega 3 polyunsaturated fatty acids are mediated by their oxygenated metabolites. This review attempts to cover the current literature about the contribution of specific omega 3 oxygenated metabolites, namely omega 3 isoprostanoids, which are produced through free-radical mediated oxidation. A special emphasis has been given to the most biologically relevant omega 3 polyunsaturated fatty acids namely the α-linolenic, eicosapentaenoic and docosahexaenoic acids. The review includes a comprehensive description of the biosynthetic pathways, a summary of studies related to the biological significance of omega 3 isoprostanoids as well as a critical description of analytical development in the field of omega 3 isoprostanoids profiling in biological samples.
据报道，ω-3多不饱和脂肪酸对健康有益，尤其是在心血管疾病和炎症性疾病领域。目前的知识表明，ω-3多不饱和脂肪酸的大部分作用是由其氧化代谢产物介导的。本综述试图涵盖有关特定ω-3氧化代谢产物（即通过自由基介导的氧化产生的ω-3异前列腺素）贡献的当前文献。特别强调了最具生物学相关性的ω-3多不饱和脂肪酸，即α-亚麻酸、二十碳五烯酸和二十二碳六烯酸。该综述包括生物合成途径的全面描述、与ω-3异前列腺素生物学意义相关的研究总结，以及对生物样品中ω-3异前列腺素分析方法发展的批判性描述。
